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FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility

FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility
FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility
The patient group with the best step-down profile for ovulation induction exhibited the closest match between the clinically applied and calculated starting dose of gonadotropins. Therefore, this study provides support for the concept that the individual effective FSH starting dose for gonadotropin induction of ovulation in anovulatory infertile patients can be predicted on the basis of initial screening characteristics, such as body mass index, clomiphene resistance or failure, free IGF-I and FSH. This may result in more effective patient treatment protocols, reduced complication rates and health-economic benefits.
treatment protocols, reduced complication rates and health-economic benefits
0804-4643
223-226
van Santbrink, E.J.
5cc801c6-78b0-4876-ad44-10ba975b9070
Eijkemans, M.J.
7a7d87b5-76e0-48b3-85f1-bc0f56942134
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, B.C.
a74bd2e3-1d5e-43c1-a6e8-c67c4973f484
van Santbrink, E.J.
5cc801c6-78b0-4876-ad44-10ba975b9070
Eijkemans, M.J.
7a7d87b5-76e0-48b3-85f1-bc0f56942134
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, B.C.
a74bd2e3-1d5e-43c1-a6e8-c67c4973f484

van Santbrink, E.J., Eijkemans, M.J., Macklon, N.S. and Fauser, B.C. (2002) FSH response-dose can be predicted in ovulation induction for normogonadotropic anovulatory infertility. European journal of endocrinology, 147 (2), 223-226. (doi:10.1530/eje.0.1470223). (PMID:12153744)

Record type: Article

Abstract

The patient group with the best step-down profile for ovulation induction exhibited the closest match between the clinically applied and calculated starting dose of gonadotropins. Therefore, this study provides support for the concept that the individual effective FSH starting dose for gonadotropin induction of ovulation in anovulatory infertile patients can be predicted on the basis of initial screening characteristics, such as body mass index, clomiphene resistance or failure, free IGF-I and FSH. This may result in more effective patient treatment protocols, reduced complication rates and health-economic benefits.

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More information

Published date: August 2002
Keywords: treatment protocols, reduced complication rates and health-economic benefits

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Local EPrints ID: 185667
URI: http://eprints.soton.ac.uk/id/eprint/185667
ISSN: 0804-4643
PURE UUID: 1c59fca4-5479-4bca-a15a-77dcd330bae3

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Date deposited: 19 May 2011 09:10
Last modified: 14 Mar 2024 03:15

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Contributors

Author: E.J. van Santbrink
Author: M.J. Eijkemans
Author: N.S. Macklon
Author: B.C. Fauser

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