Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antagon)


de Jong, Diederick, Macklon, Nicholas S., Eijkemans, Marinus J.C., Mannaerts, Bernadette M.J.L., Coelingh Bennink, Herjan J.T. and Fauser, Bart C.J.M. (2001) Dynamics of the development of multiple follicles during ovarian stimulation for in vitro fertilization using recombinant follicle-stimulating hormone (Puregon) and various doses of the gonadotropin-releasing hormone antagonist ganirelix (Orgalutran/Antagon). Fertility and Sterility, 75, (4), 688-693. (doi:10.1016/S0015-0282(00)01789-1). (PMID:12057752).

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Description/Abstract

Follicular growth was unaffected by the dose of GnRH antagonist. A rise in follicular phase FSH serum concentrations during the follicular phase, largely related to exogenous FSH, enabled ongoing follicular growth in all treatment groups. The effect of GnRH antagonist on late follicular phase E(2) levels could not be exclusively attributed to suppression of LH.

Item Type: Article
ISSNs: 0015-0282 (print)
Keywords: follicle development, fsh, gnrh antagonist, ganirelix, two-gonadotropin two-cell concept, estradiol, androstenedione, fsh, lh, total follicular surface area, ivf
Subjects: R Medicine > RG Gynecology and obstetrics
R Medicine > RM Therapeutics. Pharmacology
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 185679
Date Deposited: 19 May 2011 08:27
Last Modified: 27 Mar 2014 19:40
URI: http://eprints.soton.ac.uk/id/eprint/185679

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