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A pilot study involving minimal ovarian stimulation for in vitro fertilization: extending the "follicle-stimulating hormone window" combined with the gonadotropin-releasing hormone antagonist cetrorelix

A pilot study involving minimal ovarian stimulation for in vitro fertilization: extending the "follicle-stimulating hormone window" combined with the gonadotropin-releasing hormone antagonist cetrorelix
A pilot study involving minimal ovarian stimulation for in vitro fertilization: extending the "follicle-stimulating hormone window" combined with the gonadotropin-releasing hormone antagonist cetrorelix
Objective: To study whether minimal interference in the process of selection of the single dominant follicle may serve as the basis for a simplified ovarian stimulation regimen for IVF.

Design: Single-center randomized pilot study.

Setting: Tertiary referral fertility center.

Patient(s): Fifteen normo-ovulatory patients with a regular indication for IVF.

Intervention(s): Ovarian stimulation for IVF was begun with 100 or 150 IU/d recombinant FSH starting on cycle day 5. From cycle day 8 or later, cotreatment was begun with 0.25 mg/d GnRH antagonist. No luteal support was provided.

Main Outcome Measure(s): Total number of dominant follicles and characteristics of the endocrine cycle.

Result(s): Multiple follicle development occurred in five of eight patients in the 100-IU group and in all seven women in the 150-IU group. Follicular phase and luteal phase lengths were normal, but the endocrine profile was abnormal.

Conclusion(s): A fixed daily dose of 150 IU recombinant FSH starting in the midfollicular phase resulted in ongoing growth of a restricted number of dominant follicles and sufficient oocytes retrieved to lead to ET. A marked reduction in the total amount of gonadotropins administered compared with standard treatment was achieved. Withholding luteal support did not exclude pregnancies.
ivf, recombinant fsh, gnrh antagonist, minimal ovarian stimulation
0015-0282
1051-1054
de Jong, D.
78242841-0be8-4721-b604-871742987b2d
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, B.C.
a74bd2e3-1d5e-43c1-a6e8-c67c4973f484
de Jong, D.
78242841-0be8-4721-b604-871742987b2d
Macklon, N.S.
7db1f4fc-a9f6-431f-a1f2-297bb8c9fb7e
Fauser, B.C.
a74bd2e3-1d5e-43c1-a6e8-c67c4973f484

de Jong, D., Macklon, N.S. and Fauser, B.C. (2000) A pilot study involving minimal ovarian stimulation for in vitro fertilization: extending the "follicle-stimulating hormone window" combined with the gonadotropin-releasing hormone antagonist cetrorelix. Fertility and Sterility, 73 (5), 1051-1054. (doi:10.1016/S0015-0282(00)00414-3). (PMID:11704146)

Record type: Article

Abstract

Objective: To study whether minimal interference in the process of selection of the single dominant follicle may serve as the basis for a simplified ovarian stimulation regimen for IVF.

Design: Single-center randomized pilot study.

Setting: Tertiary referral fertility center.

Patient(s): Fifteen normo-ovulatory patients with a regular indication for IVF.

Intervention(s): Ovarian stimulation for IVF was begun with 100 or 150 IU/d recombinant FSH starting on cycle day 5. From cycle day 8 or later, cotreatment was begun with 0.25 mg/d GnRH antagonist. No luteal support was provided.

Main Outcome Measure(s): Total number of dominant follicles and characteristics of the endocrine cycle.

Result(s): Multiple follicle development occurred in five of eight patients in the 100-IU group and in all seven women in the 150-IU group. Follicular phase and luteal phase lengths were normal, but the endocrine profile was abnormal.

Conclusion(s): A fixed daily dose of 150 IU recombinant FSH starting in the midfollicular phase resulted in ongoing growth of a restricted number of dominant follicles and sufficient oocytes retrieved to lead to ET. A marked reduction in the total amount of gonadotropins administered compared with standard treatment was achieved. Withholding luteal support did not exclude pregnancies.

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More information

Published date: May 2000
Keywords: ivf, recombinant fsh, gnrh antagonist, minimal ovarian stimulation

Identifiers

Local EPrints ID: 185683
URI: http://eprints.soton.ac.uk/id/eprint/185683
ISSN: 0015-0282
PURE UUID: e067fd97-bf3f-4dbc-8b98-b42ce37bd280

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Date deposited: 20 May 2011 08:17
Last modified: 14 Mar 2024 03:15

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Contributors

Author: D. de Jong
Author: N.S. Macklon
Author: B.C. Fauser

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