Thrombocytopenia, antithrombin deficiency and extensive thromboembolism in pregnancy: treatment with low-molecular-weight heparin
Macklon, N.S., Greer, I.A., Reid, A.W. and Walker, I.D. (1995) Thrombocytopenia, antithrombin deficiency and extensive thromboembolism in pregnancy: treatment with low-molecular-weight heparin. Blood Coagulation & Fibrinolysis, 6, (7), 672-675. (PMID:8562839).
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Description/Abstract
Pregnancy limits the therapeutic options for managing thrombocytopenia which occurs in 5% of patients on heparin. We describe a case of extensive thromboembolism associated with antithrombin (AT) deficiency complicated by thrombocytopenia which resolved when low-molecular-weight heparin was instituted. A primigravid woman presented at 11 weeks gestation with bilateral femoral occlusive thrombi extending above the renal veins. Investigations revealed AT deficiency, thrombocytopenia and renal infarction. After low-molecular-weight heparin was substituted for unfractionated heparin, the thrombocytopenia resolved and although the pregnancy was lost, the patient made a full recovery.
| Item Type: | Article |
|---|---|
| ISSNs: | 0957-5235 (print) |
| Related URLs: | |
| Subjects: | R Medicine > RB Pathology R Medicine > RG Gynecology and obstetrics R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease |
| Item ID: | 185707 |
| Date Deposited: | 20 May 2011 13:00 |
| Last Modified: | 01 Jun 2011 13:02 |
| Contributors: | Macklon, N.S. (Author) Greer, I.A. (Author) Reid, A.W. (Author) Walker, I.D. (Author) |
| Date: | October 1995 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/185707 |
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