A total synthesis of toddaquinoline exposes a dual role for cobalt in radical additions to pyridines
Harrowven, D. C., Nunn, M. I. T., Blumire, N. J. and Fenwick, D. R. (2000) A total synthesis of toddaquinoline exposes a dual role for cobalt in radical additions to pyridines. Tetrahedron Letters, 41, (34), 6681-6683. (doi:10.1016/S0040-4039(00)01119-9).
Full text not available from this repository.
This paper describes the first total synthesis of toddaquinoline, an alkaloid from the root bark of Formosan Toddalia asiatica. importantly, the synthesis has exposed a dichotomy in radical reactions mediated by tin and cobalt(I) that involve additions to pyridines. Our observations suggest that cobalt plays a dual role in such reactions: firstly initiating homolysis of the carbon to halogen bond, then acting as a Lewis acid to promote radical additions to the carbon centre adjacent to nitrogen.
|Digital Object Identifier (DOI):||doi:10.1016/S0040-4039(00)01119-9|
|Keywords:||radicals and radical reactions, natural products, polycyclic heterocyclic compounds, cobalt and its compounds, photochemistry, pyridines|
Q Science > QD Chemistry
|Divisions :||University Structure - Pre August 2011 > School of Chemistry
|Accepted Date and Publication Date:||
|Date Deposited:||12 Dec 2005|
|Last Modified:||31 Mar 2016 11:35|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
Actions (login required)