Thermally cleavable safety-catch linkers for solid phase chemistry


Russell, H. E., Luke, R. W. A. and Bradley, M. (2000) Thermally cleavable safety-catch linkers for solid phase chemistry. Tetrahedron Letters, 41, (27), 5287-5290. (doi:10.1016/S0040-4039(00)00807-8).

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Description/Abstract

Safety-catch linkers based on the sulfoxide/selenoxide syn elimination have been developed. Clean and efficient oxidation of the sulfide to the sulfoxide was achieved with the homogeneous oxidising system comprising of hexafluoroisopropanol (HFIP) and hydrogen peroxide. Elimination of the sulfoxide was only possible with the most activated of substrates, while the selenoxide underwent cleavage under much milder conditions.

Item Type: Article
Related URLs:
Keywords: organic-synthesis, acids
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 18854
Date Deposited: 15 Dec 2005
Last Modified: 27 Mar 2014 18:08
URI: http://eprints.soton.ac.uk/id/eprint/18854

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