Thermally cleavable safety-catch linkers for solid phase chemistry
Russell, H. E., Luke, R. W. A. and Bradley, M. (2000) Thermally cleavable safety-catch linkers for solid phase chemistry. Tetrahedron Letters, 41, (27), 5287-5290. (doi:10.1016/S0040-4039(00)00807-8)
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Official URL: http://dx.doi.org/10.1016/S0040-4039(00)00807-8
Description/Abstract
Safety-catch linkers based on the sulfoxide/selenoxide syn elimination have been developed. Clean and efficient oxidation of the sulfide to the sulfoxide was achieved with the homogeneous oxidising system comprising of hexafluoroisopropanol (HFIP) and hydrogen peroxide. Elimination of the sulfoxide was only possible with the most activated of substrates, while the selenoxide underwent cleavage under much milder conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | organic-synthesis, acids |
| Related URLs: | http://dx.doi.org/10.1016/S004...00)00807-8 |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| ePrint ID: | 18854 |
| URI: | http://eprints.soton.ac.uk/id/eprint/18854 |
| Deposited On: | 15 Dec 2005 |
| Last Modified: | 01 Jun 2011 17:06 |
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