Synthesis of trifluoromethylpyrroles and related heterocycles from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one

Andrew, R. J. and Mellor, J. M. (2000) Synthesis of trifluoromethylpyrroles and related heterocycles from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one. Tetrahedron, 56, (37), 7267-7272. (doi:10.1016/S0040-4020(00)00598-6).


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Syntheses cf intermediate 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones are described from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one and alpha-aminoacids. In subsequent cyclisations pyrroles and other bicyclic heteroaromatics having trifluoromethyl substitution are obtained either by simple dehydration or with concomitant decarboxylation.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0040-4020(00)00598-6
Related URLs:
Keywords: amino acids, pyrroles, thiaproline, trifluoromethyl haloacetylated enol ethers, fluorine-containing 1,2-dihydropyrimidines, structural determination, nitrogen-heterocycles, efficient synthesis, magnetic-resonance, facile synthesis, convenient, cyclization, ketones
Subjects: Q Science
Q Science > QD Chemistry
Divisions : University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 18865
Accepted Date and Publication Date:
8 September 2000Published
Date Deposited: 16 Dec 2005
Last Modified: 31 Mar 2016 11:35

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