Synthesis of trifluoromethylpyrroles and related heterocycles from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one
Andrew, R. J. and Mellor, J. M. (2000) Synthesis of trifluoromethylpyrroles and related heterocycles from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one. Tetrahedron, 56, (37), 7267-7272. (doi:10.1016/S0040-4020(00)00598-6).
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Original Publication URL: http://dx.doi.org/10.1016/S0040-4020(00)00598-6
Description/Abstract
Syntheses cf intermediate 4-dialkylamino-1,1,1-trifluorobut-3-ene-2-ones are described from 4-ethyloxy-1,1,1-trifluorobut-3-ene-2-one and alpha-aminoacids. In subsequent cyclisations pyrroles and other bicyclic heteroaromatics having trifluoromethyl substitution are obtained either by simple dehydration or with concomitant decarboxylation.
| Item Type: | Article |
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| Related URLs: | |
| Keywords: | amino acids, pyrroles, thiaproline, trifluoromethyl haloacetylated enol ethers, fluorine-containing 1,2-dihydropyrimidines, structural determination, nitrogen-heterocycles, efficient synthesis, magnetic-resonance, facile synthesis, convenient, cyclization, ketones |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 18865 |
| Date Deposited: | 16 Dec 2005 |
| Last Modified: | 01 Jun 2011 13:33 |
| Contributors: | Andrew, R. J. (Author) Mellor, J. M. (Author) |
| Date: | 8 September 2000 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/18865 |
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