Structure-activity relationships in anti-neoplastic: type I amphiphiles
Dymond, M.K. and Attard, G.S. (2000) Structure-activity relationships in anti-neoplastic: type I amphiphiles. Biochemistry, 39, (6), 1572. (doi:10.1021/bi9950995).
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HDPC and ET-18-OMe, both type I amphiphiles and analogues of the naturally occurring biomembrane component lysophosphatidylcholine, are potent anti-neoplastic agents. A series of novel, type I amphiphiles have been synthesized, and their cytostatic activity against cancer cells in culture was determined. The data suggest that cytostatic activity is a generic property of type I amphiphiles. Furthermore, the primary target for these amphiphiles appears to be the inhibition of phosphatidylcholine synthesis via perturbation in the elastic properties of intracellular bilayer membranes.
|Digital Object Identifier (DOI):||doi:10.1021/bi9950995|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||17 Jan 2006|
|Last Modified:||06 Aug 2015 02:18|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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