Structure-activity relationships in anti-neoplastic: type I amphiphiles


Dymond, M.K. and Attard, G.S. (2000) Structure-activity relationships in anti-neoplastic: type I amphiphiles. Biochemistry, 39, (6), 1572. (doi: 10.1021/bi9950995).

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Original Publication URL: http://dx.doi.org/10.1021/bi9950995

Description/Abstract

HDPC and ET-18-OMe, both type I amphiphiles and analogues of the naturally occurring biomembrane component lysophosphatidylcholine, are potent anti-neoplastic agents. A series of novel, type I amphiphiles have been synthesized, and their cytostatic activity against cancer cells in culture was determined. The data suggest that cytostatic activity is a generic property of type I amphiphiles. Furthermore, the primary target for these amphiphiles appears to be the inhibition of phosphatidylcholine synthesis via perturbation in the elastic properties of intracellular bilayer membranes.

Item Type: Article
Related URLs:
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 18898
Date Deposited: 17 Jan 2006
Last Modified: 27 Mar 2014 18:08
URI: http://eprints.soton.ac.uk/id/eprint/18898

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