Structure-activity relationships in anti-neoplastic: type I amphiphiles
Dymond, M.K. and Attard, G.S. (2000) Structure-activity relationships in anti-neoplastic: type I amphiphiles. Biochemistry, 39, (6), 1572. (doi: 10.1021/bi9950995)
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Official URL: http://dx.doi.org/10.1021/bi9950995
Description/Abstract
HDPC and ET-18-OMe, both type I amphiphiles and analogues of the naturally occurring biomembrane component lysophosphatidylcholine, are potent anti-neoplastic agents. A series of novel, type I amphiphiles have been synthesized, and their cytostatic activity against cancer cells in culture was determined. The data suggest that cytostatic activity is a generic property of type I amphiphiles. Furthermore, the primary target for these amphiphiles appears to be the inhibition of phosphatidylcholine synthesis via perturbation in the elastic properties of intracellular bilayer membranes.
| Item Type: | Article |
|---|---|
| Related URLs: | http://dx.doi.org/10.1021/bi9950995 |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| ePrint ID: | 18898 |
| URI: | http://eprints.soton.ac.uk/id/eprint/18898 |
| Deposited On: | 17 Jan 2006 |
| Last Modified: | 01 Jun 2011 14:33 |
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