Solid-phase synthesis of amidine-based GP IIb-IIIa antagonists on dendrimer resin beads


Basso, A., Pegg, N., Evans, B. and Bradley, M. (2000) Solid-phase synthesis of amidine-based GP IIb-IIIa antagonists on dendrimer resin beads. European Journal of Organic Chemistry, (23), 3887-3891. (doi: 10.1002/1099-0690(200012)2000:23<3887::AID-EJOC3887>3.0.CO;2-T).

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Description/Abstract

Many amidine-based molecules are known to be antagonists of the fibrinogen-GP IIb-IIIa interaction, therefore useful in the treatment of thrombotic deseases. Here we report the solid-phase synthesis of a small library of amidines, starting from high-loading dendrimerised TentaGel beads, using resin-bound 4-amidinobenzoic acid as a template. These compounds mimic the structure of known active compounds like Lamifiban (Ro44-9883) and TAK-029; the first solid-phase synthesis of which is also reported in this paper.

Item Type: Article
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Keywords: solid-phase organic synthesis, dendrimers, amidines, ro44-9883 fibrinogen receptor antagonists, peptide-synthesis, inhibitors, derivatives, reagent, design
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 18911
Date Deposited: 17 Jan 2006
Last Modified: 27 Mar 2014 18:08
URI: http://eprints.soton.ac.uk/id/eprint/18911

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