Solid-phase synthesis of amidine-based GP IIb-IIIa antagonists on dendrimer resin beads
Basso, A., Pegg, N., Evans, B. and Bradley, M. (2000) Solid-phase synthesis of amidine-based GP IIb-IIIa antagonists on dendrimer resin beads. European Journal of Organic Chemistry, (23), 3887-3891. (doi: 10.1002/1099-0690(200012)2000:23<3887::AID-EJOC3887>3.0.CO;2-T).
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Description/Abstract
Many amidine-based molecules are known to be antagonists of the fibrinogen-GP IIb-IIIa interaction, therefore useful in the treatment of thrombotic deseases. Here we report the solid-phase synthesis of a small library of amidines, starting from high-loading dendrimerised TentaGel beads, using resin-bound 4-amidinobenzoic acid as a template. These compounds mimic the structure of known active compounds like Lamifiban (Ro44-9883) and TAK-029; the first solid-phase synthesis of which is also reported in this paper.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Keywords: | solid-phase organic synthesis, dendrimers, amidines, ro44-9883 fibrinogen receptor antagonists, peptide-synthesis, inhibitors, derivatives, reagent, design |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 18911 |
| Date Deposited: | 17 Jan 2006 |
| Last Modified: | 31 May 2011 23:27 |
| Contributors: | Basso, A. (Author) Pegg, N. (Author) Evans, B. (Author) Bradley, M. (Author) |
| Date: | 1 December 2000 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/18911 |
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