A selenide linker for "traceless" solid-phase organic synthesis

Li, Z. G., Kulkarni, B. A. and Ganesan, A. (2000) A selenide linker for "traceless" solid-phase organic synthesis. Biotechnology and Bioengineering, 71, (2), 104-106. (doi:10.1002/1097-0290(2000)71:2<104::AID-BIT1000>3.0.CO;2-7).


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4-Bromophenethyl alcohol was protected as the THP ether, followed by reaction with magnesium and selenium to give the corresponding diselenide. Ether deprotection provides a diselenide diol, which is attached to solid-phase resins. The polymer-bound selenide anion is then generated, and functions as a traceless linker for electrophiles such as alkyl halides.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/1097-0290(2000)71:2<104::AID-BIT1000>3.0.CO;2-7
Related URLs:
Keywords: solid-phase synthesis, traceless linkers, selenides strategies, cleavage
Subjects: Q Science
Q Science > QD Chemistry
Divisions : University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 18917
Accepted Date and Publication Date:
Date Deposited: 18 Jan 2006
Last Modified: 31 Mar 2016 11:35
URI: http://eprints.soton.ac.uk/id/eprint/18917

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