A safety-catch linker for amine release under biologically compatible conditions
A safety-catch linker for amine release under biologically compatible conditions
A "biocompatible" safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.
amines, diketopiperazine, solid phase organic synthesis (spos)
solid-phase synthesis, loading resin beads, combinatorial chemistry, organic-synthesis, trypanothione reductase, peptide libraries, singlebead, discovery, generation, cleavage
25-34
Orain, D.
84d12c1f-c2ce-4b53-9f6a-61e75e7b49ca
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
2000
Orain, D.
84d12c1f-c2ce-4b53-9f6a-61e75e7b49ca
Bradley, M.
078a34d6-96c4-4ce1-9aa1-454d9ee0030d
Orain, D. and Bradley, M.
(2000)
A safety-catch linker for amine release under biologically compatible conditions.
Molecular Diversity, 5 (1), .
(doi:10.1023/A:1011355300910).
Abstract
A "biocompatible" safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.
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Published date: 2000
Keywords:
amines, diketopiperazine, solid phase organic synthesis (spos)
solid-phase synthesis, loading resin beads, combinatorial chemistry, organic-synthesis, trypanothione reductase, peptide libraries, singlebead, discovery, generation, cleavage
Identifiers
Local EPrints ID: 18919
URI: http://eprints.soton.ac.uk/id/eprint/18919
PURE UUID: 26eecfd0-3acd-4065-9022-c516aabdfe77
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Date deposited: 19 Jan 2006
Last modified: 15 Mar 2024 06:09
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Author:
D. Orain
Author:
M. Bradley
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