A safety-catch linker for amine release under biologically compatible conditions
Orain, D. and Bradley, M. (2000) A safety-catch linker for amine release under biologically compatible conditions. Molecular Diversity, 5, (1), 25-34. (doi:10.1023/A:1011355300910).
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A "biocompatible" safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.
|Digital Object Identifier (DOI):||doi:10.1023/A:1011355300910|
|Keywords:||amines, diketopiperazine, solid phase organic synthesis (spos) solid-phase synthesis, loading resin beads, combinatorial chemistry, organic-synthesis, trypanothione reductase, peptide libraries, singlebead, discovery, generation, cleavage|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||19 Jan 2006|
|Last Modified:||31 Mar 2016 11:35|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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