A safety-catch linker for amine release under biologically compatible conditions

Orain, D. and Bradley, M. (2000) A safety-catch linker for amine release under biologically compatible conditions. Molecular Diversity, 5, (1), 25-34. (doi:10.1023/A:1011355300910).


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A "biocompatible" safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1023/A:1011355300910
Related URLs:
Keywords: amines, diketopiperazine, solid phase organic synthesis (spos) solid-phase synthesis, loading resin beads, combinatorial chemistry, organic-synthesis, trypanothione reductase, peptide libraries, singlebead, discovery, generation, cleavage
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 18919
Date :
Date Event
Date Deposited: 19 Jan 2006
Last Modified: 31 Mar 2016 11:35
URI: http://eprints.soton.ac.uk/id/eprint/18919

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