A safety-catch linker for amine release under biologically compatible conditions
Orain, D. and Bradley, M. (2000) A safety-catch linker for amine release under biologically compatible conditions. Molecular Diversity, 5, (1), 25-34. (doi: 10.1023/A:1011355300910).
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Description/Abstract
A "biocompatible" safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.
| Item Type: | Article |
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| Related URLs: | |
| Keywords: | amines, diketopiperazine, solid phase organic synthesis (spos) solid-phase synthesis, loading resin beads, combinatorial chemistry, organic-synthesis, trypanothione reductase, peptide libraries, singlebead, discovery, generation, cleavage |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 18919 |
| Date Deposited: | 19 Jan 2006 |
| Last Modified: | 01 Jun 2011 11:01 |
| Contributors: | Orain, D. (Author) Bradley, M. (Author) |
| Date: | 2000 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/18919 |
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