Effects of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles


Maeda, Eijiro, Shelton, Julia C., Bader, Dan L. and Lee, David A. (2009) Effects of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomedical Science and Engineering, 4, (4), 510-517. (doi:10.1299/jbse.4.510). (PMID:17719009).

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Description/Abstract

Intermittent pattern of mechanical stimulation has been demonstrated to possess different regulatory effects on cell metabolism in many connective tissues, but little is known about tenocyte responses.A previous study has shown that the application of a small number of continuous cyclic strain inhibited collagen synthesis by tenocytes in explants, whereas a large number of strain cycles upregulated the synthesis. Thus the present study tested the hypothesis that collagen synthesis is influenced by cyclic tensile strain provided in an intermittent manner.A total of 43,200 cycles of tensile strain, with a 3% amplitude superimposed on a 2% static strain was provided in four different intermittent patterns with different strain/unstrain periods: 10 minutes, 1 hour, 6 hours and 12 hours. The amount of newly synthesised collagen, both those retained in strained fascicles and released into culture media, were not significantly altered by the application of different patterns of intermittent cyclic strain. The present findings may suggest that, unlike other connective tissue cells, tenocyte responses are predominantly regulated by the total number of strain cells.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1299/jbse.4.510
ISSNs: 1937-6871 (print)
1937-688X (electronic)
Related URLs:
Keywords: tendon, fascicle, cyclic strain, collagen, tenocyte, metabolism
Subjects: R Medicine > RA Public aspects of medicine
Divisions : University Structure - Pre August 2011 > School of Medicine
ePrint ID: 189385
Accepted Date and Publication Date:
Status
April 2009Published
Date Deposited: 19 Jan 2012 12:46
Last Modified: 31 Mar 2016 13:40
URI: http://eprints.soton.ac.uk/id/eprint/189385

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