Optimising inhibitors of trypanothione reductase using solid-phase chemistry
Chitkul, B. and Bradley, M. (2000) Optimising inhibitors of trypanothione reductase using solid-phase chemistry. Bioorganic and Medicinal Chemistry Letters, 10, (20), 2367-2369. (doi:10.1016/S0960-894X(00)00471-6).
Download
Full text not available from this repository.
Original Publication URL: http://dx.doi.org/10.1016/S0960-894X(00)00471-6
Description/Abstract
A series of inhibitors of the enzyme trypanothione reductase has been identified using directed solid-phase chemistry. The compounds were based on a series of polyamine scaffolds and used the natural product kukoamine A as the lead structure. A compound with a K-i of 76 nM was identified, although somewhat surprisingly the compound appeared to be noncompetitive in nature.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Keywords: | trypanosoma-cruzi, target, design, potent, drugs |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 18942 |
| Date Deposited: | 19 Jan 2006 |
| Last Modified: | 01 Jun 2011 13:35 |
| Contributors: | Chitkul, B. (Author) Bradley, M. (Author) |
| Date: | 16 October 2000 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/18942 |
Actions (login required)
 |
View Item |
