e-Prints Soton - A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis

A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis

May, P. J., Bradley, M., Harrowven, D. C. and Pallin, D. (2000) A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis. Tetrahedron Letters, 41, (10), 1627-1630. (doi:10.1016/S0040-4039(99)02345-X)
http://eprints.soton.ac.uk/18951/

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Official URL: http://dx.doi.org/10.1016/S004...99)02345-X

Abstract

Resin bound thioesters can be prepared by heating thioamides in aqueous DMF with Merrifield resin in the presence of sodium iodide. These thioamides can be cleaved to give alcohols, ketones and lactones by a variety of methods.

Item Type:	Article
Uncontrolled Keywords:	combinatorial chemistry, lactones, solid phase synthesis, thioamide, thioestersilyl enol ethers, organic-synthesis, esters
Subjects:	Q Science Q Science > QD Chemistry
School or Centre:	School of Chemistry
ID Code:	18951
Deposited By:	SOC, Import
Deposited On:	15 December 2005

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