A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis


May, P. J., Bradley, M., Harrowven, D. C. and Pallin, D. (2000) A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis. Tetrahedron Letters, 41, (10), 1627-1630. (doi:10.1016/S0040-4039(99)02345-X).

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Description/Abstract

Resin bound thioesters can be prepared by heating thioamides in aqueous DMF with Merrifield resin in the presence of sodium iodide. These thioamides can be cleaved to give alcohols, ketones and lactones by a variety of methods.

Item Type: Article
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Keywords: combinatorial chemistry, lactones, solid phase synthesis, thioamide, thioestersilyl enol ethers, organic-synthesis, esters
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 18951
Date Deposited: 15 Dec 2005
Last Modified: 27 Mar 2014 18:08
URI: http://eprints.soton.ac.uk/id/eprint/18951

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