A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis
May, P. J., Bradley, M., Harrowven, D. C. and Pallin, D. (2000) A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis. Tetrahedron Letters, 41, (10), 1627-1630. (doi:10.1016/S0040-4039(99)02345-X).
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Original Publication URL: http://dx.doi.org/10.1016/S0040-4039(99)02345-X
Description/Abstract
Resin bound thioesters can be prepared by heating thioamides in aqueous DMF with Merrifield resin in the presence of sodium iodide. These thioamides can be cleaved to give alcohols, ketones and lactones by a variety of methods.
| Item Type: | Article |
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| Related URLs: | |
| Keywords: | combinatorial chemistry, lactones, solid phase synthesis, thioamide, thioestersilyl enol ethers, organic-synthesis, esters |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 18951 |
| Date Deposited: | 15 Dec 2005 |
| Last Modified: | 31 May 2011 23:28 |
| Contributors: | May, P. J. (Author) Bradley, M. (Author) Harrowven, D. C. (Author) Pallin, D. (Author) |
| Date: | 4 March 2000 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/18951 |
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