A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis
May, P. J., Bradley, M., Harrowven, D. C. and Pallin, D. (2000) A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis. Tetrahedron Letters, 41, (10), 1627-1630. (doi:10.1016/S0040-4039(99)02345-X).
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Resin bound thioesters can be prepared by heating thioamides in aqueous DMF with Merrifield resin in the presence of sodium iodide. These thioamides can be cleaved to give alcohols, ketones and lactones by a variety of methods.
|Keywords:||combinatorial chemistry, lactones, solid phase synthesis, thioamide, thioestersilyl enol ethers, organic-synthesis, esters|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||15 Dec 2005|
|Last Modified:||27 Mar 2014 18:08|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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