Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound.

Vollmer, Brigitte, Roth, Simon, Baudin, Jenny, Stewart, Ann L., Neville, Brian G. R. and Wyatt, John S. (2003) Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound. Pediatrics, 112, (5), 1108-1114. (doi:10.1542/peds.112.5.1108). (PMID:14595054).


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Objectives. To investigate the effect of
gestational age at birth on the frequency of ultrasounddetected
brain lesions in infants born at <33 weeks of
gestation and to investigate whether the relationship between
neonatal cranial ultrasound diagnosis and neurodevelopmental
outcome at 8 years of age was independent
of gestational age.
Methods. Eight hundred forty-seven infants born at
<33 weeks of gestation, admitted to a single tertiary
referral center between 1983 and 1988, underwent serial
neonatal cranial ultrasound. At 8 years of age neurodevelopmental
outcome was assessed by structured neurologic
examination, psychometric tests (Wechsler Intelligence
Scale for Children), tests of visuomotor integration
(Beery) and motor impairment (Henderson-Stott). Infants
were subdivided into a group born at <28 weeks and a
group born at between 28 and 32 weeks. Neurodevelopmental
outcome was analyzed for each ultrasound diagnosis.
Results. Hemorrhagic lesions such as germinal matrix/
intraventricular hemorrhage and hemorrhagic parenchymal
infarction were more frequent in infants born at
<28 weeks. There was no difference in the frequency of
cystic periventricular leucomalacia between the 2 groups.
When neurodevelopmental outcome for each ultrasound
diagnosis was compared, no significant difference was
found between the 2 gestational age groups.
Conclusion. In the gestational age range studied, adverse
neurodevelopmental outcome depends primarily
on the type of the intracranial lesion rather than on
gestational age. Pediatrics 2003;112:1108 –1114; very preterm
infant, neonatal cranial ultrasound, neurodevelopmental
outcome, brain lesions, gestational age.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1542/peds.112.5.1108
ISSNs: 0031-4005 (print)
1098-4275 (electronic)
Related URLs:
Subjects: R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 189523
Date Deposited: 02 Jun 2011 14:38
Last Modified: 27 Mar 2014 19:42

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