Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound.
Vollmer, Brigitte, Roth, Simon, Baudin, Jenny, Stewart, Ann L., Neville, Brian G. R. and Wyatt, John S. (2003) Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound. Pediatrics, 112, (5), 1108-1114. (doi:10.1542/peds.112.5.1108). (PMID:14595054).
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Description/Abstract
Objectives. To investigate the effect of
gestational age at birth on the frequency of ultrasounddetected
brain lesions in infants born at <33 weeks of
gestation and to investigate whether the relationship between
neonatal cranial ultrasound diagnosis and neurodevelopmental
outcome at 8 years of age was independent
of gestational age.
Methods. Eight hundred forty-seven infants born at
<33 weeks of gestation, admitted to a single tertiary
referral center between 1983 and 1988, underwent serial
neonatal cranial ultrasound. At 8 years of age neurodevelopmental
outcome was assessed by structured neurologic
examination, psychometric tests (Wechsler Intelligence
Scale for Children), tests of visuomotor integration
(Beery) and motor impairment (Henderson-Stott). Infants
were subdivided into a group born at <28 weeks and a
group born at between 28 and 32 weeks. Neurodevelopmental
outcome was analyzed for each ultrasound diagnosis.
Results. Hemorrhagic lesions such as germinal matrix/
intraventricular hemorrhage and hemorrhagic parenchymal
infarction were more frequent in infants born at
<28 weeks. There was no difference in the frequency of
cystic periventricular leucomalacia between the 2 groups.
When neurodevelopmental outcome for each ultrasound
diagnosis was compared, no significant difference was
found between the 2 gestational age groups.
Conclusion. In the gestational age range studied, adverse
neurodevelopmental outcome depends primarily
on the type of the intracranial lesion rather than on
gestational age. Pediatrics 2003;112:1108 –1114; very preterm
infant, neonatal cranial ultrasound, neurodevelopmental
outcome, brain lesions, gestational age.
| Item Type: | Article |
|---|---|
| ISSNs: | 0031-4005 (print) 1098-4275 (electronic) |
| Related URLs: | |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences |
| Item ID: | 189523 |
| Date Deposited: | 02 Jun 2011 14:38 |
| Last Modified: | 02 Mar 2012 12:37 |
| Contributors: | Vollmer, Brigitte (Author) Roth, Simon (Author) Baudin, Jenny (Author) Stewart, Ann L. (Author) Neville, Brian G. R. (Author) Wyatt, John S. (Author) |
| Date: | 1 November 2003 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/189523 |
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