Bilateral spastic cerebral palsy--MRI pathology and origin. Analysis from a representative series of 56 cases.


Krägeloh-Mann, Ingeborg, Petersen, Dirk, Hagberg, Gudrun, Vollmer, Brigitte, Hagberg, Bengt and Michaelis, Richard (1995) Bilateral spastic cerebral palsy--MRI pathology and origin. Analysis from a representative series of 56 cases. Developmental Medicine & Child Neurology, 37, (5), 379-397. (doi:10.1111/j.1469-8749.1995.tb12022.x). (PMID:8566452).

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Description/Abstract

MRI of the brain was performed on 56 children with bilateral spastic cerebral palsy (CP) at a mean age of 10.7 years. Specific pathology was found in 91 per cent; periventricular leukomalacia was present in 42 per cent of term- and 87 per cent of preterm-born children. Parasagittal subcorticocortical injury, multicystic encephalomalacia and basal ganglia lesions were identified in 16 per cent, in all but one associated with severe peri-/neonatal events at term or near term. Maldevelopment comprised 9 per cent, all but one found in term-born children. MRI morphology correlated strikingly with outcome. Periventricular leukomalacia was associated with more severe disability in term- than preterm-born children.

Item Type: Article
ISSNs: 0012-1622 (print)
1469-8749 (electronic)
Subjects: R Medicine > RB Pathology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RJ Pediatrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Clinical Neurosciences
ePrint ID: 189533
Date Deposited: 02 Jun 2011 15:27
Last Modified: 27 Mar 2014 19:42
URI: http://eprints.soton.ac.uk/id/eprint/189533

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