New approach to β-lactam-fused enediynes ("lactenediynes") by stereoselective pinacol coupling
Banfi, L., Guanti, G. and Basso, A. (2000) New approach to β-lactam-fused enediynes ("lactenediynes") by stereoselective pinacol coupling. European Journal of Organic Chemistry, (6), 939-946. (doi: 10.1002/(SICI)1099-0690(200003)2000:6<939::AID-EJOC939>3.0.CO;2-Q)
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Official URL: http://www3.interscience.wiley.com/cgi-bin/abstrac...
Description/Abstract
A short synthesis of unfunctionalized lactenediyne 3 by closure of the ten-membered ring at the double bond site is reported. After failure of the known methodologies, this closure was eventually successfully achieved thanks to a highly stereoselective, vanadium(II)-mediated pinacol coupling of bis(alk-2-ynal) 7.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | enediynes, vanadium, pinacol coupling, macrocycles, lactams cyclic enediynes, dynemicin-a, conjugated enediynes, system, ring, 1,2-diols, aldehydes, design, cycloaromatization, lactendiynes |
| Related URLs: | http://www3.interscience.wiley...6/ABSTRACT |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| ePrint ID: | 18954 |
| URI: | http://eprints.soton.ac.uk/id/eprint/18954 |
| Deposited On: | 18 Jan 2006 |
| Last Modified: | 02 Mar 2012 12:03 |
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