Modulation of CTP : phosphocholine cytidylyltransferase by membrane curvature elastic stress

Attard, G. S., Templer, R. H., Smith, W. S., Hunt, A. N. and Jackowski, S. (2000) Modulation of CTP : phosphocholine cytidylyltransferase by membrane curvature elastic stress. Proceedings of the National Academy of Sciences of the United States of America, 97, (16), 9032-9036. (doi:10.1073/pnas.160260697).


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The activity of CTP:phosphocholine cytidylyltransferase, a rate-limiting enzyme in phosphatidylcholine biosynthesis, is modulated by its interaction with lipid bilayers [Kent, C. (1997) Biochim, Biophys, Acta 1348, 79-90]. Its regulation is of central importance in the maintenance of membrane lipid homeostasis, Here we show evidence that the stored curvature elastic stress in the lipid membrane's monolayer modulates the activity of CTP:phosphocholine cytidylyltransferase. Our results show how a purely physical feedback signal could play a key role in the control of membrane lipid synthesis.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1073/pnas.160260697
Related URLs:
Keywords: bilayer-forming lipids, phosphatidylcholine biosynthesis, acholeplasma-laidlawii, binding domain, phase-behavior, 1-o-octadecyl-2-o-methyl-rac-glycero-3-phosphocholine, lysophosphatidylcholine, cells, phospholipids, cholesterol
Subjects: Q Science
Q Science > QD Chemistry
Divisions : University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 18967
Accepted Date and Publication Date:
1 August 2000Published
Date Deposited: 19 Jan 2006
Last Modified: 31 Mar 2016 11:35

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