Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters


Childs, Caroline E., Romijn, Tessa, Enke, Ute, Hoile, Samuel P. and Calder, Philip C. (2010) Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. Prostaglandins Leukotrienes and Essential Fatty Acids, 83, (4), 179-183. (doi:10.1016/j.plefa.2010.08.007). (PMID:20817424).

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Description/Abstract

Both animalandhumanstudiesdemonstratethatthedocosahexaenoicacid(DHA)contentofplasma
and/ortissuelipidsisincreasedduringpregnancy.Wehypothesisedthatincreasingthe a-linolenicacid
(ALA)orlongerchain(n-3) PUFAcontentofthematernaldietduringpregnancyinfluencesfetalfatty
acid compositionandthefetalimmunesystem.Pregnantratswerefedalow-fat(LF)soybeanoildiet,or
high-fat(HF)soybean,linseed,salmonorsunfloweroildietsfromconceptionto20dgestation.The
ALA-richLinseed-HFdietresultedinanequivalenteicosapentaenoicacid(EPA)statusinfetalimmune
tissuesandanequivalentDHAstatusinthefetalbraintothatachievedwiththeSalmon-HFdiet.An
(n-3) richmaternaldietduringpregnancyassociatedwiththehighestexpressionofCD3(Salmon-HF)
and CD8(Linseed-HFandSalmon-HF)onfetalthymicCD3+CD8+ cells. TheLinseed-HFdietresultedin
the highestproportionofCD161+ cells withinthefetalthymus,whichcorrelatedwiththeproductionof
IL-4. ThesedataindicatethatdietaryALAsupplementationmayconfersomeofthebenefitsofLC(n-3)
PUFA duringpregnancy.Thisshouldbeexaminedinsuitablydesignedhumanstudies

Item Type: Article
ISSNs: 0952-3278 (print)
Related URLs:
Keywords: fetal, immune, omega-3
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RG Gynecology and obstetrics
Divisions: University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
ePrint ID: 190945
Date Deposited: 16 Jun 2011 11:57
Last Modified: 27 Mar 2014 19:43
URI: http://eprints.soton.ac.uk/id/eprint/190945

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