Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters
Childs, Caroline E., Romijn, Tessa, Enke, Ute, Hoile, Samuel P. and Calder, Philip C. (2010) Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. Prostaglandins Leukotrienes and Essential Fatty Acids, 83, (4), 179-183. (doi:10.1016/j.plefa.2010.08.007). (PMID:20817424).
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Description/Abstract
Both animalandhumanstudiesdemonstratethatthedocosahexaenoicacid(DHA)contentofplasma
and/ortissuelipidsisincreasedduringpregnancy.Wehypothesisedthatincreasingthe a-linolenicacid
(ALA)orlongerchain(n-3) PUFAcontentofthematernaldietduringpregnancyinfluencesfetalfatty
acid compositionandthefetalimmunesystem.Pregnantratswerefedalow-fat(LF)soybeanoildiet,or
high-fat(HF)soybean,linseed,salmonorsunfloweroildietsfromconceptionto20dgestation.The
ALA-richLinseed-HFdietresultedinanequivalenteicosapentaenoicacid(EPA)statusinfetalimmune
tissuesandanequivalentDHAstatusinthefetalbraintothatachievedwiththeSalmon-HFdiet.An
(n-3) richmaternaldietduringpregnancyassociatedwiththehighestexpressionofCD3(Salmon-HF)
and CD8(Linseed-HFandSalmon-HF)onfetalthymicCD3+CD8+ cells. TheLinseed-HFdietresultedin
the highestproportionofCD161+ cells withinthefetalthymus,whichcorrelatedwiththeproductionof
IL-4. ThesedataindicatethatdietaryALAsupplementationmayconfersomeofthebenefitsofLC(n-3)
PUFA duringpregnancy.Thisshouldbeexaminedinsuitablydesignedhumanstudies
| Item Type: | Article |
|---|---|
| ISSNs: | 0952-3278 (print) |
| Related URLs: | |
| Keywords: | fetal, immune, omega-3 |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) R Medicine > RG Gynecology and obstetrics |
| Divisions: | University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease |
| Item ID: | 190945 |
| Date Deposited: | 16 Jun 2011 11:57 |
| Last Modified: | 01 Jul 2011 01:11 |
| Contributors: | Childs, Caroline E. (Author) Romijn, Tessa (Author) Enke, Ute (Author) Hoile, Samuel P. (Author) Calder, Philip C. (Author) |
| Date: | October 2010 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/190945 |
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