Airway inflammation and atopic asthma: a comparative bronchoscopic investigation


Howarth, P.H., Wilson, J., Djukanovic, R., Wilson, S.J., Britten, K., Walls, A.F., Roche, W.R. and Holgate, S.T. (1991) Airway inflammation and atopic asthma: a comparative bronchoscopic investigation. International Archives of Allergy and Applied Immunology, 94, (1-4), 266-269. (doi:10.1159/000235379). (PMID:1937887).

Download

Full text not available from this repository.

Description/Abstract

Flexible fibre-optic bronchoscopy under local anaesthesia has been used to investigate the cellular airway events in atopic asthma. The findings have been compared to those from atopic individuals without asthma and non-atopic healthy controls, in an attempt to discern those changes relevant to clinical disease expression. Immunohistochemical and electron-microscopic analyses of airway biopsies identified that an atopic diathesis is associated with tissue eosinophil infiltration and mast cell degranulation. The eosinophilia was greatest in those atopic individuals with asthma. Flow-cytometric analysis of airway lavage revealed significantly enhanced T lymphocyte activation in clinical asthma. These findings are consistent with the hypothesis that T lymphocyte activation, through cytokine release, amplifies the tissue eosinophilia in asthma and that this combination is associated with clinical disease expression.

Item Type: Article
ISSNs: 1018-2438 (print)
1423-0097 (electronic)
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RB Pathology
R Medicine > RF Otorhinolaryngology
Divisions: University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 190997
Date Deposited: 20 Jun 2011 14:12
Last Modified: 27 Mar 2014 19:43
URI: http://eprints.soton.ac.uk/id/eprint/190997

Actions (login required)

View Item View Item