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Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients

Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients
Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients
Preliminary observations of the clinical efficacy of intravenous immunoglobulin in two patients with severe corticosteroid insensitive asthma are reported. In both patients treatment with intravenous immunoglobulin resulted in clinical improvement and enabled a significant reduction in the dose of prednisolone. In one of the patients fibreoptic bronchoscopy with endobronchial biopsies was performed and peripheral blood was analysed by flow cytometry before and after treatment. Immunohistological analysis of the biopsy samples after treatment showed a decrease in the number of all cell types, especially CD3+ T cells, CD4+ T cells, and activated CD25+ T lymphocytes, which was associated with a reduction in peripheral blood T cell activation. Intravenous immunoglobulin may be a valid option for the treatment of corticosteroid insensitive asthma. To elucidate the role and mode of action of intravenous immunoglobulin further studies in larger groups of patients are needed.
0040-6376
662-664
Vrugt, B.
d4c28d43-9943-42f4-b9f4-d3c082a6a2e4
Wilson, S.J.
21c6875d-6870-441b-ae7a-603562a646b8
van Velzen, E.
40ea3da6-d1b0-46a5-a849-f39700f188bd
Bron, A.
e0354c49-ecc0-411b-9b75-a9c5e3dc5837
Shute, J.K.
21aa47b2-7a14-4706-981d-f6cc6be58bf4
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Djukanovic, R.
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Aalbers, R.
d505a4b7-d33b-463e-a807-1c1a1cbb8896
Vrugt, B.
d4c28d43-9943-42f4-b9f4-d3c082a6a2e4
Wilson, S.J.
21c6875d-6870-441b-ae7a-603562a646b8
van Velzen, E.
40ea3da6-d1b0-46a5-a849-f39700f188bd
Bron, A.
e0354c49-ecc0-411b-9b75-a9c5e3dc5837
Shute, J.K.
21aa47b2-7a14-4706-981d-f6cc6be58bf4
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Djukanovic, R.
d9a45ee7-6a80-4d84-a0ed-10962660a98d
Aalbers, R.
d505a4b7-d33b-463e-a807-1c1a1cbb8896

Vrugt, B., Wilson, S.J., van Velzen, E., Bron, A., Shute, J.K., Holgate, S.T., Djukanovic, R. and Aalbers, R. (1997) Effects of high dose intravenous immunoglobulin in two severe corticosteroid insensitive asthmatic patients. Thorax, 52 (7), 662-664. (doi:10.1136/thx.52.7.662). (PMID:8096001)

Record type: Article

Abstract

Preliminary observations of the clinical efficacy of intravenous immunoglobulin in two patients with severe corticosteroid insensitive asthma are reported. In both patients treatment with intravenous immunoglobulin resulted in clinical improvement and enabled a significant reduction in the dose of prednisolone. In one of the patients fibreoptic bronchoscopy with endobronchial biopsies was performed and peripheral blood was analysed by flow cytometry before and after treatment. Immunohistological analysis of the biopsy samples after treatment showed a decrease in the number of all cell types, especially CD3+ T cells, CD4+ T cells, and activated CD25+ T lymphocytes, which was associated with a reduction in peripheral blood T cell activation. Intravenous immunoglobulin may be a valid option for the treatment of corticosteroid insensitive asthma. To elucidate the role and mode of action of intravenous immunoglobulin further studies in larger groups of patients are needed.

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Published date: July 1997

Identifiers

Local EPrints ID: 191007
URI: http://eprints.soton.ac.uk/id/eprint/191007
ISSN: 0040-6376
PURE UUID: 0c7704f9-4fc5-4f64-87ea-438b566bf018
ORCID for S.J. Wilson: ORCID iD orcid.org/0000-0003-1305-8271
ORCID for R. Djukanovic: ORCID iD orcid.org/0000-0001-6039-5612

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Date deposited: 21 Jun 2011 10:47
Last modified: 15 Mar 2024 02:36

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Contributors

Author: B. Vrugt
Author: S.J. Wilson ORCID iD
Author: E. van Velzen
Author: A. Bron
Author: J.K. Shute
Author: S.T. Holgate
Author: R. Djukanovic ORCID iD
Author: R. Aalbers

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