Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy
Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy
Evidence for the involvement of inflammatory processes in the pathogenesis of Alzheimer's disease (AD) has been documented for a long time. However, the inflammation hypothesis in relation to AD pathology has emerged relatively recently. Even in this hypothesis, the inflammatory reaction is still considered to be a downstream effect of the accumulated proteins (amyloid beta (Abeta) and tau). This review aims to highlight the importance of the immune processes involved in AD pathogenesis based on the outcomes of the two major inflammation-relevant treatment strategies against AD developed and tested to date in animal studies and human clinical trials - the use of anti-inflammatory drugs and immunisation against Abeta
1-9
Zotova, Elina
3558dd45-67a7-4e7a-b2ef-a9155ca784e8
Nicoll, James A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Kalaria, Raj
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Holmes, Clive
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Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
22 January 2010
Zotova, Elina
3558dd45-67a7-4e7a-b2ef-a9155ca784e8
Nicoll, James A.R.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Kalaria, Raj
80b4b094-c190-49c5-8c6e-ccc69ec2297b
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Zotova, Elina, Nicoll, James A.R., Kalaria, Raj, Holmes, Clive and Boche, Delphine
(2010)
Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy.
Alzheimer's Research & Therapy, 2 (1), .
(doi:10.1186/alzrt24).
(PMID:20122289)
Abstract
Evidence for the involvement of inflammatory processes in the pathogenesis of Alzheimer's disease (AD) has been documented for a long time. However, the inflammation hypothesis in relation to AD pathology has emerged relatively recently. Even in this hypothesis, the inflammatory reaction is still considered to be a downstream effect of the accumulated proteins (amyloid beta (Abeta) and tau). This review aims to highlight the importance of the immune processes involved in AD pathogenesis based on the outcomes of the two major inflammation-relevant treatment strategies against AD developed and tested to date in animal studies and human clinical trials - the use of anti-inflammatory drugs and immunisation against Abeta
Text
2010 Alzheimer's research&therapy.pdf
- Accepted Manuscript
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Published date: 22 January 2010
Identifiers
Local EPrints ID: 191157
URI: http://eprints.soton.ac.uk/id/eprint/191157
ISSN: 1758-9193
PURE UUID: 5e91c06b-3183-4601-8301-633d46f12f6e
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Date deposited: 17 Jun 2011 07:54
Last modified: 15 Mar 2024 03:13
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Author:
Elina Zotova
Author:
Raj Kalaria
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