Directed formation of DNA nanoarrays through orthogonal self-assembly


Burns, Jonathan R., Zekonyte, Jurgita, Siligardi, Giuliano, Hussain, Rohanah and Stulz, Eugen (2011) Directed formation of DNA nanoarrays through orthogonal self-assembly. Molecules, 16, (6), 4912-4922. (doi:10.3390/molecules16064912). (PMID:21677604).

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Description/Abstract

We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II)and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.

Item Type: Article
ISSNs: 1420-3049 (print)
1420-3049 (electronic)
Keywords: terpy-dna, afm, tem, dna nanotubes
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH426 Genetics
T Technology > TP Chemical technology
Divisions: University Structure - Pre August 2011 > School of Chemistry
University Structure - Pre August 2011 > School of Engineering Sciences
ePrint ID: 191665
Date Deposited: 23 Jun 2011 12:29
Last Modified: 27 Mar 2014 19:43
Research Funder: EPSRC
Projects:
Nanoscale Multifunctional Molecules using DNA as scaffold
Funded by: EPSRC (EP/E045693/1)
Led by: Eugen Stulz
25 June 2007 to 24 December 2010
URI: http://eprints.soton.ac.uk/id/eprint/191665

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