Directed formation of DNA nanoarrays through orthogonal self-assembly
Burns, Jonathan R., Zekonyte, Jurgita, Siligardi, Giuliano, Hussain, Rohanah and Stulz, Eugen (2011) Directed formation of DNA nanoarrays through orthogonal self-assembly. Molecules, 16, (6), 4912-4922. (doi:10.3390/molecules16064912). (PMID:21677604).
We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II)and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
|Keywords:||terpy-dna, afm, tem, dna nanotubes|
|Subjects:||Q Science > QD Chemistry
Q Science > QH Natural history > QH426 Genetics
T Technology > TP Chemical technology
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
University Structure - Pre August 2011 > School of Engineering Sciences
|Date Deposited:||23 Jun 2011 12:29|
|Last Modified:||19 Jul 2012 10:49|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
Actions (login required)