Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior

Langley, K., Turic, D., Rice, F., Holmans, P., van den Bree, M.B.M., Craddock, N., Kent, L., Owen, M.J., O'Donovan, M.C. and Thapar, A. (2007) Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, (1), 49-53. (doi:10.1002/ajmg.b.30571). (PMID:17579368).


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Gene?×?environment (G?×?E) interactions are increasingly thought to have substantial influence on the aetiology and clinical manifestations of complex disorders. In ADHD, although main effects of specific genetic variants and pre- or peri-natal variables have been reported and replicated using pooled analyses, few studies have looked at possible interactions. In a clinical sample of 266 children with ADHD, we tested for interaction between gene variants (in DRD4, DAT1, DRD5, and 5HTT) found to be associated with ADHD in pooled analyses and maternal smoking, alcohol use during pregnancy and birth weight. First, G?×?E effects on a diagnosis of ADHD were tested using conditional logistic regression analyses. Second, possible modifying effects of G?×?E on symptoms of associated conduct disorder and oppositional defiant disorder (ODD) were investigated using linear regression analysis. The sample size associated with each of the analyses differed as not each variant had been genotyped for each individual. No effects of G?×?E on ADHD diagnosis were observed. The results suggest that lower birth weight and maternal smoking during pregnancy may interact with DRD5 and DAT1 (birth weight only) in influencing associated antisocial behavior symptoms (ODD and conduct disorder). These preliminary findings showed no evidence of interaction between previously implicated variants in ADHD and specific environmental risk factors, on diagnosis of the disorder. There may be evidence of G?×?E on associated antisocial behavior in ADHD, but further investigation is needed.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1002/ajmg.b.30571
ISSNs: 1552-4841 (print)
1552-485X (electronic)
Keywords: gene?×?environment interaction, birth weight, maternal smoking during pregnancy, social class
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RG Gynecology and obstetrics
Divisions : University Structure - Pre August 2011 > School of Psychology > Division of Clinical Neuroscience
ePrint ID: 192211
Accepted Date and Publication Date:
Date Deposited: 30 Jun 2011 12:47
Last Modified: 31 Mar 2016 13:42
URI: http://eprints.soton.ac.uk/id/eprint/192211

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