The University of Southampton
University of Southampton Institutional Repository

Tissue factor: biological function and clinical significance

Tissue factor: biological function and clinical significance
Tissue factor: biological function and clinical significance
Tissue Factor is the principal cellular initiator of normal blood coagulation. It is frequently encrypted in the plasma membrane of cells in contact with blood, but under certain pathological conditions endothelial cells, monocytes or macrophages may express tissue factor; and hence trigger coagulation activation. Aberrant expression of tissue factor by these cells is thought to be responsible for the thrombophilia found in septic shock, atherosclerosis and cancer. Tissue factor is produced by tumor-associated macrophages where it is believed to play an important role in tumor growth and dissemination. It may also be involved in other cellular processes such as intracellular signalling, angiogenesis and embryonic blood-vessel development. Tissue factor can be found both as free (soluble tissue factor) and membrane bound forms. Several studies have shown that measurements of any of these forms may provided clinically significant information, particularly in patients with malignant and inflammatory diseases, and are cost-effective.
tissue factor, forms, assays clinical importance, review
135-143
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Lwaleed, Bashir A.
e7c59131-82ad-4a14-a227-7370e91e3f21

Lwaleed, Bashir A. (2002) Tissue factor: biological function and clinical significance. Saudi Medical Journal, 23 (2), 135-143.

Record type: Article

Abstract

Tissue Factor is the principal cellular initiator of normal blood coagulation. It is frequently encrypted in the plasma membrane of cells in contact with blood, but under certain pathological conditions endothelial cells, monocytes or macrophages may express tissue factor; and hence trigger coagulation activation. Aberrant expression of tissue factor by these cells is thought to be responsible for the thrombophilia found in septic shock, atherosclerosis and cancer. Tissue factor is produced by tumor-associated macrophages where it is believed to play an important role in tumor growth and dissemination. It may also be involved in other cellular processes such as intracellular signalling, angiogenesis and embryonic blood-vessel development. Tissue factor can be found both as free (soluble tissue factor) and membrane bound forms. Several studies have shown that measurements of any of these forms may provided clinically significant information, particularly in patients with malignant and inflammatory diseases, and are cost-effective.

This record has no associated files available for download.

More information

Published date: 2002
Keywords: tissue factor, forms, assays clinical importance, review

Identifiers

Local EPrints ID: 19254
URI: http://eprints.soton.ac.uk/id/eprint/19254
PURE UUID: af49d54b-d198-49df-86e3-e6355f48491b
ORCID for Bashir A. Lwaleed: ORCID iD orcid.org/0000-0001-5748-4892

Catalogue record

Date deposited: 01 Feb 2006
Last modified: 06 Aug 2024 01:39

Export record

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×