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Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization

Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization
Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization
Meningococcal carriage and the immune response to colonization were studied in a group of military recruits undergoing basic training. Subtyping by determination of the class 1 protein sequence clearly differentiated between strains and demonstrated the dynamics of carriage and transmission. Expression of class 1 protein by each strain remained stable during prolonged carriage by different subjects. Following colonization, a marked increase in serum bactericidal response occurred, which was specific for the subtype of the acquired strain and was associated with an increase in reactivity by Western blot to the homologous class 1 protein. Subjects colonized by multiple strains showed evidence of a specific immune response to the class 1 protein of each strain acquired. The subtype specificity of the bactericidal response to meningococci and the stability of expression of the class 1 protein have important implications for the design of vaccines for prevention of serogroup B meningococcal disease.
0022-1899
451-459
Jones, Graeme R.
c8160cbd-efdb-476e-a95a-82301c69a4ae
Christodoulides, M
eba99148-620c-452a-a334-c1a52ba94078
Brooks, J
cd96ddbd-c20d-44d9-9f99-c3ba63ad5e6c
Miller, A
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Cartwright, K A
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Heckels, John E.
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31
Jones, Graeme R.
c8160cbd-efdb-476e-a95a-82301c69a4ae
Christodoulides, M
eba99148-620c-452a-a334-c1a52ba94078
Brooks, J
cd96ddbd-c20d-44d9-9f99-c3ba63ad5e6c
Miller, A
3ba3a59c-aa1e-4178-9c55-8e237314b93a
Cartwright, K A
fa68f4c1-916e-4c89-a002-8562910dd548
Heckels, John E.
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31

Jones, Graeme R., Christodoulides, M, Brooks, J, Miller, A, Cartwright, K A and Heckels, John E. (1998) Dynamics of carriage of Neisseria meningitidis in a group of military recruits: subtype stability and specificity of the immune response following colonization. Journal of Infectious Diseases, 178 (2), 451-459. (PMID:9697726)

Record type: Article

Abstract

Meningococcal carriage and the immune response to colonization were studied in a group of military recruits undergoing basic training. Subtyping by determination of the class 1 protein sequence clearly differentiated between strains and demonstrated the dynamics of carriage and transmission. Expression of class 1 protein by each strain remained stable during prolonged carriage by different subjects. Following colonization, a marked increase in serum bactericidal response occurred, which was specific for the subtype of the acquired strain and was associated with an increase in reactivity by Western blot to the homologous class 1 protein. Subjects colonized by multiple strains showed evidence of a specific immune response to the class 1 protein of each strain acquired. The subtype specificity of the bactericidal response to meningococci and the stability of expression of the class 1 protein have important implications for the design of vaccines for prevention of serogroup B meningococcal disease.

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More information

Published date: August 1998
Organisations: Infection Inflammation & Immunity

Identifiers

Local EPrints ID: 193817
URI: http://eprints.soton.ac.uk/id/eprint/193817
ISSN: 0022-1899
PURE UUID: 90f7c552-966e-4214-b2b4-3a5d4b0342a6
ORCID for M Christodoulides: ORCID iD orcid.org/0000-0002-9663-4731

Catalogue record

Date deposited: 20 Jul 2011 13:46
Last modified: 23 Jul 2022 01:33

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Contributors

Author: Graeme R. Jones
Author: J Brooks
Author: A Miller
Author: K A Cartwright
Author: John E. Heckels

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