Solid-phase Friedel-Crafts acylation on polystyrene resins-synthesis of antiepiletic 1-aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones


Bevacqua, F., Basso, A., Gitto, R., Bradley, M. and Chimirri, A. (2001) Solid-phase Friedel-Crafts acylation on polystyrene resins-synthesis of antiepiletic 1-aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones. Tetrahedron Letters, 42, (43), 7683-7685. (doi:10.1016/S0040-4039(01)01602-1).

Download

Full text not available from this repository.

Description/Abstract

Friedel-Crafts acylation with various acyl chlorides of resin-bound 3,4-dimethoxyphenylacetate afforded resin bound ketones which, following treatment with hydrazine, were converted into the corresponding 2,3-benzodiazepines in good yields and purities.

Item Type: Article
Related URLs:
Keywords: solid-phase synthesis, friedel-crafts acylation, 2,3-benzodiazepines ampa receptor antagonists
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 19406
Date Deposited: 14 Feb 2006
Last Modified: 27 Mar 2014 18:09
URI: http://eprints.soton.ac.uk/id/eprint/19406

Actions (login required)

View Item View Item