Synthesis and biological activity of analogues of ptilomycalin A

Black, G. P., Coles, S. J., Hizi, A., Howard-Jones, A. G., Hursthouse, M. B., McGown, A. T., Loya, S., Moore, C. G., Murphy, P. J., Smith, N. K. and Walshe, N. D. A. (2001) Synthesis and biological activity of analogues of ptilomycalin A. Tetrahedron Letters, 42, (19), 3377-3381. (doi:10.1016/S0040-4039(01)00400-2).


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Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). (C) 2001 Elsevier Science Ltd. All rights reserved.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0040-4039(01)00400-2
Related URLs:
Subjects: Q Science
Q Science > QD Chemistry
Divisions : University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 19412
Accepted Date and Publication Date:
7 May 2001Published
Date Deposited: 14 Feb 2006
Last Modified: 31 Mar 2016 11:36

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