Synthesis and biological activity of analogues of ptilomycalin A
Black, G. P., Coles, S. J., Hizi, A., Howard-Jones, A. G., Hursthouse, M. B., McGown, A. T., Loya, S., Moore, C. G., Murphy, P. J., Smith, N. K. and Walshe, N. D. A. (2001) Synthesis and biological activity of analogues of ptilomycalin A. Tetrahedron Letters, 42, (19), 3377-3381. (doi:10.1016/S0040-4039(01)00400-2).
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Description/Abstract
Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). (C) 2001 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
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| Related URLs: | |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 19412 |
| Date Deposited: | 14 Feb 2006 |
| Last Modified: | 01 Jun 2011 03:55 |
| Contributors: | Black, G. P. (Author) Coles, S. J. (Author) Hizi, A. (Author) Howard-Jones, A. G. (Author) Hursthouse, M. B. (Author) McGown, A. T. (Author) Loya, S. (Author) Moore, C. G. (Author) Murphy, P. J. (Author) Smith, N. K. (Author) Walshe, N. D. A. (Author) |
| Date: | 7 May 2001 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/19412 |
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