Enantioselective binding of dipeptides using acyclic receptors
Botana, E., Ongeri, S., Arienzo, R., Demarcus, M., Frey, J. G., Piarulli, U., Potenza, D., Gennari, C. and Kilburn, J. D. (2001) Enantioselective binding of dipeptides using acyclic receptors. Chemical Communications, (15), 1358-1359. (doi:10.1039/b102383g)
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Official URL: http://dx.doi.org/10.1039/b102383g
Description/Abstract
Novel receptors featuring a 2,6-diamidopyridine 'head' group and bearing sulfonamidopeptide sidearms have been prepared on the solid-phase; one receptor showed high selectivity for N-Cbz-D-Ala-D-AlaOH over its enantiomer N-Cbz-L-Ala-L-AlaOH, but absolute binding constants were relatively weak, which can be understood in terms of receptors which have to unfold, breaking intramolecular hydrogen bonds, in order to accommodate the guests.
| Item Type: | Article |
|---|---|
| Additional Information: | ChemComm |
| Uncontrolled Keywords: | synthetic receptors, tweezers, peptides |
| Related URLs: | http://dx.doi.org/10.1039/b102383g |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| ePrint ID: | 19421 |
| URI: | http://eprints.soton.ac.uk/id/eprint/19421 |
| Deposited On: | 14 Feb 2006 |
| Last Modified: | 01 Apr 2012 01:55 |
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