The VP3 gene of human group C rotavirus

Samarbaf-Zadeh, Ali Reza, Lambden, Paul R., Green, Steve, Deng, Yu, Caul, E. Owen and Clarke, Ian N. (1996) The VP3 gene of human group C rotavirus. Virus Genes, 13, (2), 169-173. (doi:10.1007/BF00568909). (PMID:8972570).


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The complete nucleotide sequence of genome segment 4 from the human group C rotavirus (Bristol strain) was determined. Comparison of the nucleotide sequences of the genome termini with the consensus 5' and 3' terminal non-coding sequences of the human group C rotavirus genome revealed characteristic 5' and 3' sequence motifs. Human group C rotavirus genome segment 4 is 2,166bp long and encodes a single open reading frame of 2,082 nucleotides (693 amino acids) starting at nucleotide 55 and terminating at nucleotide 2,136 giving a 3' untranslated region of 30 nucleotides. Alignment with the porcine group C VP3 equivalent gene showed the human gene is one amino acid longer, and that the proteins have 84.1% amino acid sequence identity. A conserved potential nucleotide binding motif shared with the porcine VP3 sequence was identified. Analogy with the group A rotaviruses suggested that the genome segment 4 encodes the group C rotavirus guanylyltransferase.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1007/BF00568909
ISSNs: 0920-8569 (print)
1572-994X (electronic)
Keywords: rotavirus, dsrna, vp3 gene
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR355 Virology
R Medicine > RB Pathology
Divisions : University Structure - Pre August 2011 > School of Medicine > Infection, Inflammation and Repair
ePrint ID: 194303
Accepted Date and Publication Date:
January 1996Published
Date Deposited: 27 Jul 2011 08:52
Last Modified: 31 Mar 2016 13:43

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