Synthesis of a modified thymidine monomer for site-specific incorporation of reporter groups into oligonucleotides
Brown, L.J., May, J.P. and Brown, T. (2001) Synthesis of a modified thymidine monomer for site-specific incorporation of reporter groups into oligonucleotides. Tetrahedron Letters, 42, (13), 2587-2591. (doi:10.1016/S0040-4039(01)00224-6).
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The efficient incorporation of reporter groups into oligonucleotides at specific sites has been facilitated by the synthesis of a novel modified thymidine monomer with an FMOC-protected hydroxyl group on a linker. The primary hydroxyl group can be deprotected during or after solid-phase oligonucleotide synthesis and reacted with any reporter phosphoramidite.
|Keywords:||fluorescence energy-transfer, dye-labeled primers, dna, hybridization, probes|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||14 Feb 2006|
|Last Modified:||23 Jan 2013 13:24|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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