Regional differences in treatment for osteoporosis: The global longitudinal study of osteoporosis in women(GLOW)

Diez-Perez, Adolfo, Hooven, Frederick H., Adachi, Jonathan D., Adami, Silvano, Anderson, Frederick A., Boonen, Steven, Chapurlat, Roland, Compston, Juliet E., Cooper, Cyrus, Delmas, Pierre, Greenspan, Susan L., Lacroix, Andrea Z., Lindsay, Robert, Netelenbos, J. Coen, Pfeilschifter, Johannes, Roux, Christian, Saag, Kenneth G., Sambrook, Philip, Silverman, Stuart, Siris, Ethel S., Watts, Nelson B., Nika, Grigor and Gehlbach, Stephen H. (2011) Regional differences in treatment for osteoporosis: The global longitudinal study of osteoporosis in women(GLOW). Bone, 49, (3), 493-498. (doi:10.1016/j.bone.2011.05.007). (PMID:21605715).


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Among 58,009 women, current anti-osteoporosis medication use was lowest in Northern Europe (16%) and highest in USA and Australia (32%). Between 48% (USA, Southern Europe) and 68% (Northern Europe) of women aged ? 65 years with a history of spine or hip fracture since age 45 were untreated. Among women with osteoporosis, the percentage of treated cases was lowest in Europe (45–52% versus 62–65% elsewhere). Women with osteopenia and no other risk factors were treated with anti-osteoporosis medication most frequently in USA (31%) and Canada (31%), and least frequently in Southern Europe (12%), Northern Europe (13%), and Australia (16%). After adjusting for risk factors, US women were threefold as likely to be treated with anti-osteoporosis medication as Northern European women (odds ratio 2.8; 95% confidence interval 2.5–3.1) and 1.5 times as likely to be treated as Southern European women (1.5, 1.4–1.6). Up to half of women reporting previous hip or spine fracture did not receive treatment.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.bone.2011.05.007
ISSNs: 8756-3282 (print)
8756-3282 (electronic)
Keywords: fracture, regional variation, women, risk factor, preventive treatment
Subjects: G Geography. Anthropology. Recreation > G Geography (General)
H Social Sciences > HA Statistics
R Medicine > RA Public aspects of medicine
Divisions : University Structure - Pre August 2011 > School of Medicine
ePrint ID: 194379
Accepted Date and Publication Date:
14 May 2011Published
Date Deposited: 27 Jul 2011 13:52
Last Modified: 31 Mar 2016 13:43

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