Defining potential to benefit from implantable cardioverter defibrillator therapy: the role of biomarkers


Scott, Paul A., Townsend, Paul A., Ng, Leong L., Zeb, Mehmood, Harris, Scott, Roderick, Paul J., Curzen, Nick P. and Morgan, John M. (2011) Defining potential to benefit from implantable cardioverter defibrillator therapy: the role of biomarkers. Europace, 13, (10), 1419-1427. (doi:10.1093/europace/eur147). (PMID:21784745).

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Description/Abstract

Aims: Implantable cardioverter defibrillator (ICD) therapy improves survival in patients at high sudden cardiac death (SCD) risk. However, some patient groups fulfilling indications for ICD therapy may not gain significant benefit: patients whose absolute risk of SCD is low and patients whose risk of death even with an ICD is high. The value of biomarkers in identifying patients’ potential for survival benefit from ICD therapy is unknown. We performed a pilot study to investigate this.

Methods and results: Five established cardiovascular biomarkers were measured in patients with ICDs on the background of left ventricular dysfunction: N-terminal pro-brain natriuretic peptide [NT-proBNP], soluble ST2 [sST2], growth differentiation factor-15, C-reactive protein, and interleukin-6. The endpoints were all-cause mortality and survival with appropriate ICD therapy. One hundred and fifty-six patients were enrolled (age 69 years [Q1–Q3 62–77], 85% male, 76% ischaemic aetiology). During a follow-up of 15 ± 3 months, 12 patients died and 43 survived with appropriate ICD therapy. In a Cox proportional hazards model, the strongest predictors of death were Log sST2 (P< 0.001), serum creatinine (P< 0.001), and Log NT-proBNP (P= 0.002). The strongest predictor of survival with appropriate ICD therapy was Log NT-proBNP (P= 0.01).

Conclusion: The biomarkers NT-proBNP and sST2 are promising biomarkers for identifying patients with little potential to gain significant survival benefit from ICD therapy. However, their incremental benefit, in addition to currently available clinical risk prediction models, remains unclear. These results demand a confirmatory prospective cohort study, designed and powered to derive and validate prediction algorithms incorporating these markers.

Item Type: Article
ISSNs: 1099-5129 (print)
1532-2092 (electronic)
Keywords: implantable cardioverter defibrillators, heart failure, biomarkers, mortality, arrhythmias
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
Divisions: University Structure - Pre August 2011 > School of Medicine > Cancer Sciences
University Structure - Pre August 2011 > School of Medicine > Community Clinical Sciences
University Structure - Pre August 2011 > School of Medicine > Developmental Origins of Health and Disease
Faculty of Medicine > Primary Care and Population Sciences
ePrint ID: 194395
Date Deposited: 27 Jul 2011 12:58
Last Modified: 20 Jun 2014 13:33
URI: http://eprints.soton.ac.uk/id/eprint/194395

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