Synthesis of nucleic-acid base containing norbornene derivatives as monomers for ring-opening-metathesis-polymerization
Synthesis of nucleic-acid base containing norbornene derivatives as monomers for ring-opening-metathesis-polymerization
A series of norbornene derivatives containing nucleic-acid bases (thymine, adenine, cytosine, guanine, or uracil) have been prepared as monomers for ring-opening-metathesis-polymerization (ROMP). Many of the initially prepared monomers had poor solubility but this could be overcome by appropriate choice of a linker between the norbornene and base units. Some of the monomers were successfully polymerised to give homopolymers derived from nucleic-acid bases.
c-13 magnetic-resonance, solid-phase synthesis, amino-acids, functionalized norbornenes, bearing nucleobases, strand displacement, building-blocks, pna monomers, analogs, dna
3365-3381
Davies, R. Gareth
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Gibson, Vernon C.
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Hursthouse, Michael B.
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Light, Mark E.
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Marshall, Edward L.
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North, Michael
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Robson, David A.
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Thompson, Ian
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White, Andrew J.P.
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Williams, David J.
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Williams, Paul J.
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2001
Davies, R. Gareth
d5dfe942-fe1f-4c20-92bb-1650cd703b34
Gibson, Vernon C.
e1623bb9-29c4-490f-9b26-a5e3771ba05f
Hursthouse, Michael B.
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Light, Mark E.
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Marshall, Edward L.
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North, Michael
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Robson, David A.
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Thompson, Ian
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White, Andrew J.P.
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Williams, David J.
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Williams, Paul J.
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Davies, R. Gareth, Gibson, Vernon C., Hursthouse, Michael B., Light, Mark E., Marshall, Edward L., North, Michael, Robson, David A., Thompson, Ian, White, Andrew J.P., Williams, David J. and Williams, Paul J.
(2001)
Synthesis of nucleic-acid base containing norbornene derivatives as monomers for ring-opening-metathesis-polymerization.
Journal of the Chemical Society, Perkin Transactions 1, (24), .
(doi:10.1039/b107139d).
Abstract
A series of norbornene derivatives containing nucleic-acid bases (thymine, adenine, cytosine, guanine, or uracil) have been prepared as monomers for ring-opening-metathesis-polymerization (ROMP). Many of the initially prepared monomers had poor solubility but this could be overcome by appropriate choice of a linker between the norbornene and base units. Some of the monomers were successfully polymerised to give homopolymers derived from nucleic-acid bases.
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Published date: 2001
Keywords:
c-13 magnetic-resonance, solid-phase synthesis, amino-acids, functionalized norbornenes, bearing nucleobases, strand displacement, building-blocks, pna monomers, analogs, dna
Identifiers
Local EPrints ID: 19465
URI: http://eprints.soton.ac.uk/id/eprint/19465
ISSN: 0300-922X
PURE UUID: d11fa86f-153c-44dc-b676-897a059f4945
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Date deposited: 15 Feb 2006
Last modified: 16 Mar 2024 03:04
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Contributors
Author:
R. Gareth Davies
Author:
Vernon C. Gibson
Author:
Edward L. Marshall
Author:
Michael North
Author:
David A. Robson
Author:
Ian Thompson
Author:
Andrew J.P. White
Author:
David J. Williams
Author:
Paul J. Williams
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