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The role of histamine in asthma

The role of histamine in asthma
The role of histamine in asthma
Histamine is a ubiquitous inflammatory mediator intimately associated with the pathology of allergy. Traditional antihistamines, targeting the histamine H(1) receptor, have failed to demonstrate a significant role for histamine in asthma. Novel immunomodulatory roles for histamine and the discovery of a novel histamine receptor, the histamine H(4) receptor, have resulted in a reassessment of its importance in asthma.
0065-2598
53-66
Dunford, Paul J
ffa9d34b-cd0f-4bb9-92c5-e965b8cd2be6
Holgate, Stephen T
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Dunford, Paul J
ffa9d34b-cd0f-4bb9-92c5-e965b8cd2be6
Holgate, Stephen T
2e7c17a9-6796-436e-8772-1fe6d2ac5edc

Dunford, Paul J and Holgate, Stephen T (2011) The role of histamine in asthma. Advances in Experimental Medicine and Biology, 709, 53-66. (doi:10.1007/978-1-4419-8056-4_6). (PMID:21713689)

Record type: Article

Abstract

Histamine is a ubiquitous inflammatory mediator intimately associated with the pathology of allergy. Traditional antihistamines, targeting the histamine H(1) receptor, have failed to demonstrate a significant role for histamine in asthma. Novel immunomodulatory roles for histamine and the discovery of a novel histamine receptor, the histamine H(4) receptor, have resulted in a reassessment of its importance in asthma.

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Published date: 2011
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 194683
URI: http://eprints.soton.ac.uk/id/eprint/194683
ISSN: 0065-2598
PURE UUID: 6f5360b6-f109-4a2c-ab46-f8f5fcb427af

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Date deposited: 09 Aug 2011 14:14
Last modified: 14 Mar 2024 04:00

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Author: Paul J Dunford

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