Animal models of asthma: value, limitations and opportunities for alternative approaches
Holmes, Anthony M, Solari, Roberto and Holgate, Stephen T. (2011) Animal models of asthma: value, limitations and opportunities for alternative approaches. Drug Discovery Today, 16, (15-16), 659-670. (doi:10.1016/j.drudis.2011.05.014) (PMID:21723955)
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Description/Abstract
Asthma remains an area of considerable unmet medical need. Few new drugs have made it to the clinic during the past 50 years, with many that perform well in preclinical animal models of asthma, failing in humans owing to lack of safety and efficacy. The failure to translate promising drug candidates from animal models to humans has led to questions about the utility of in vivo studies and to demand for more predictive models and tools based on the latest technologies. Following a workshop with experts from academia and the pharmaceutical industry, we suggest here a disease modelling framework designed to better understand human asthma, and accelerate the development of safe and efficacious new asthma drugs that go beyond symptomatic relief.
| Item Type: | Article |
|---|---|
| ISSN: | 1359-6446 (print) |
| Subjects: | Q Science > QD Chemistry R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Faculty of Medicine > Infection, Inflammation and Immunity |
| ePrint ID: | 194685 |
| URI: | http://eprints.soton.ac.uk/id/eprint/194685 |
| Deposited On: | 09 Aug 2011 15:27 |
| Last Modified: | 09 Aug 2011 15:27 |
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