Animal models of asthma: value, limitations and opportunities for alternative approaches


Holmes, Anthony M, Solari, Roberto and Holgate, Stephen T. (2011) Animal models of asthma: value, limitations and opportunities for alternative approaches. Drug Discovery Today, 16, (15-16), 659-670. (doi:10.1016/j.drudis.2011.05.014 ). (PMID:21723955).

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Description/Abstract

Asthma remains an area of considerable unmet medical need. Few new drugs have made it to the clinic during the past 50 years, with many that perform well in preclinical animal models of asthma, failing in humans owing to lack of safety and efficacy. The failure to translate promising drug candidates from animal models to humans has led to questions about the utility of in vivo studies and to demand for more predictive models and tools based on the latest technologies. Following a workshop with experts from academia and the pharmaceutical industry, we suggest here a disease modelling framework designed to better understand human asthma, and accelerate the development of safe and efficacious new asthma drugs that go beyond symptomatic relief.

Item Type: Article
ISSNs: 1359-6446 (print)
Subjects: Q Science > QD Chemistry
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Faculty of Medicine > Infection, Inflammation and Immunity
ePrint ID: 194685
Date Deposited: 09 Aug 2011 14:27
Last Modified: 27 Mar 2014 19:44
URI: http://eprints.soton.ac.uk/id/eprint/194685

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