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Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation

Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation
Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation
This systematic review and economic evaluation show that patients with histologically mild HCV can be successfully treated with both pegylated and non-pegylated interferon alpha. Early treatment and watchful waiting strategies are associated with acceptable cost-per-QALY estimates. Research needs to be directed towards newer, potentially more effective interventions, particularly those that improve treatment response in patients with genotype 1, with minimal adverse effects. Further research is required into the natural history of HCV to estimate better the rate of liver disease progression, and also into the effectiveness of non-invasive biochemical markers of liver disease, as an alternative to liver biopsy
1366-5278
1-205
Shepherd, J.
dfbca97a-9307-4eee-bdf7-e27bcb02bc67
Jones, J.
270b303b-6bad-4be7-8ea0-63d0e8015c91
Hartwell, D.
8ee30d05-c758-4d82-9e40-f977cd45bd58
Davidson, P.
531fc501-2ab0-4481-900e-2e7c0cc6424d
Price, A. R.
196a82a6-0b25-4e28-9afa-899a7319f3c4
Waugh, N.
4e268891-bf0b-4baa-9933-60257822286c
Shepherd, J.
dfbca97a-9307-4eee-bdf7-e27bcb02bc67
Jones, J.
270b303b-6bad-4be7-8ea0-63d0e8015c91
Hartwell, D.
8ee30d05-c758-4d82-9e40-f977cd45bd58
Davidson, P.
531fc501-2ab0-4481-900e-2e7c0cc6424d
Price, A. R.
196a82a6-0b25-4e28-9afa-899a7319f3c4
Waugh, N.
4e268891-bf0b-4baa-9933-60257822286c

Shepherd, J., Jones, J., Hartwell, D., Davidson, P., Price, A. R. and Waugh, N. (2007) Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation. Health Technology Assessment, 11 (11), 1-205. (doi:10.3310/hta11110). (PMID:17346498)

Record type: Article

Abstract

This systematic review and economic evaluation show that patients with histologically mild HCV can be successfully treated with both pegylated and non-pegylated interferon alpha. Early treatment and watchful waiting strategies are associated with acceptable cost-per-QALY estimates. Research needs to be directed towards newer, potentially more effective interventions, particularly those that improve treatment response in patients with genotype 1, with minimal adverse effects. Further research is required into the natural history of HCV to estimate better the rate of liver disease progression, and also into the effectiveness of non-invasive biochemical markers of liver disease, as an alternative to liver biopsy

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More information

Published date: March 2007
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 194787
URI: http://eprints.soton.ac.uk/id/eprint/194787
ISSN: 1366-5278
PURE UUID: 3db8de3a-20b0-4a81-a8d1-dd4fd2d82edd
ORCID for J. Shepherd: ORCID iD orcid.org/0000-0003-1682-4330
ORCID for P. Davidson: ORCID iD orcid.org/0000-0003-0388-6356

Catalogue record

Date deposited: 11 Aug 2011 13:56
Last modified: 15 Mar 2024 03:15

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Contributors

Author: J. Shepherd ORCID iD
Author: J. Jones
Author: D. Hartwell
Author: P. Davidson ORCID iD
Author: A. R. Price
Author: N. Waugh

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