Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation


Shepherd, J., Jones, J., Hartwell, D., Davidson, P., Price, A. R. and Waugh, N. (2007) Interferon alpha (pegylated and non-pegylated) and ribavirin for the treatment of mild chronic hepatitis C: a systematic review and economic evaluation. Health Technology Assessment , 11, (11), 1-205. (doi:10.3310/hta11110). (PMID:17346498).

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Description/Abstract

This systematic review and economic evaluation show that patients with histologically mild HCV can be successfully treated with both pegylated and non-pegylated interferon alpha. Early treatment and watchful waiting strategies are associated with acceptable cost-per-QALY estimates. Research needs to be directed towards newer, potentially more effective interventions, particularly those that improve treatment response in patients with genotype 1, with minimal adverse effects. Further research is required into the natural history of HCV to estimate better the rate of liver disease progression, and also into the effectiveness of non-invasive biochemical markers of liver disease, as an alternative to liver biopsy

Item Type: Article
ISSNs: 1366-5278
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine
ePrint ID: 194787
Date Deposited: 11 Aug 2011 13:56
Last Modified: 27 Mar 2014 19:45
URI: http://eprints.soton.ac.uk/id/eprint/194787

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