Total syntheses of justicidin B and retrojusticidin B using a tandem Horner-Emmons-Claisen condensation sequence
Harrowven, D. C., Bradley, M., Castro, J. L. and Flanagan, S. R. (2001) Total syntheses of justicidin B and retrojusticidin B using a tandem Horner-Emmons-Claisen condensation sequence. Tetrahedron Letters, 42, (39), 6973-6975. (doi:10.1016/S0040-4039(01)01436-8).
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Original Publication URL: http://dx.doi.org/10.1016/S0040-4039(01)01436-8
Description/Abstract
Short syntheses of justicidin B 1 and retrojusticidin B 4 are reported. The key feature is a new annulation reaction, involving a base induced union of ketoaldehyde 2 and phosphonate 3. that is used to construct the highly substituted naphthalene core.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Keywords: | natural products, annulation, lignans, horner-emmons, claisen condensationlignan lactones, 1-arylnaphthalene lignans, arylnaphthalene lignans, neolignans, 5-lipoxygenase, cyanohydrins, inhibitors, agents, entry, cells |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 19502 |
| Date Deposited: | 14 Feb 2006 |
| Last Modified: | 01 Jun 2011 06:13 |
| Contributors: | Harrowven, D. C. (Author) Bradley, M. (Author) Castro, J. L. (Author) Flanagan, S. R. (Author) |
| Date: | 24 September 2001 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/19502 |
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