Effect of omalizumab on peripheral blood eosinophilia in allergic asthma


Massanari, M., Holgate, S.T., Busse, W.W., Jimenez, P., Kianifard, F. and Zeldin, R. (2010) Effect of omalizumab on peripheral blood eosinophilia in allergic asthma. Respiratory Medicine, 104, (2), 188-196. (doi:10.1016/j.rmed.2009.09.011). (PMID:19846286).

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Description/Abstract

Eosinophilia is an established marker of asthma-related inflammation. We assessed the effect of omalizumab on peripheral blood eosinophil counts using a pooled analysis of data from five randomized, double-blind, placebo-controlled studies in patients with moderate-to-severe persistent allergic asthma receiving moderate-to-high-dose inhaled corticosteroids (omalizumab, n=1136; placebo, n=1100). Relationships between omalizumab, peripheral blood eosinophils, serum free IgE concentrations and clinical outcomes were explored. Baseline mean eosinophil counts were similar in each treatment group. Post-treatment eosinophil counts were significantly reduced from baseline in the omalizumab group (p<0.0001) but were not significantly different in the placebo group. Greater reductions in eosinophil counts were observed in patients who had post-treatment free IgE levels <50ng/mL. Three studies included steroid-stable and steroid-reduction phases. At the end of each phase in these studies, a significantly greater reduction in eosinophil counts was achieved in the omalizumab group compared with the placebo group (p<0.0001). A consistent pattern of improved clinical outcomes/decreased eosinophils and worsened clinical outcomes/increased eosinophils was observed for both omalizumab and placebo treatment groups. The findings from our analysis of a large patient population are consistent with earlier reports of the inhibitory effect of omalizumab on eosinophils.

Item Type: Article
ISSNs: 0954-6111 (print)
Keywords: omalizumab, ige, eosinophils, allergy, asthma
Subjects: Q Science > QR Microbiology > QR180 Immunology
R Medicine > RB Pathology
R Medicine > RF Otorhinolaryngology
Divisions: Faculty of Medicine > Infection, Inflammation and Immunity
ePrint ID: 195245
Date Deposited: 17 Aug 2011 14:49
Last Modified: 27 Mar 2014 19:45
URI: http://eprints.soton.ac.uk/id/eprint/195245

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