Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening
Orain, D. and Bradley, M. (2001) Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening. Tetrahedron Letters, 42, (3), 515-518. (doi:10.1016/S0040-4039(00)02009-8).
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Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.
|Keywords:||resin, solid phase synthesis, trypanothione reductase combinatorial libraries, peptide libraries, organic-synthesis, drugdiscovery, specificity, generation, binding, resin|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||14 Feb 2006|
|Last Modified:||31 May 2011 23:28|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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