Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening
Orain, D. and Bradley, M. (2001) Solid phase synthesis of trypanothione reductase inhibitors - towards single bead screening. Tetrahedron Letters, 42, (3), 515-518. (doi:10.1016/S0040-4039(00)02009-8)
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Official URL: http://dx.doi.org/10.1016/S0040-4039(00)02009-8
Description/Abstract
Using solid phase chemistry, inhibitors of trypanothione reductase were synthesised on TentaGel resin using a biologically compatible safety-catch linker. The material released was of high purity, while cleavage kinetics indicated the potential of the system for multiple release.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | resin, solid phase synthesis, trypanothione reductase combinatorial libraries, peptide libraries, organic-synthesis, drugdiscovery, specificity, generation, binding, resin |
| Related URLs: | http://dx.doi.org/10.1016/S004...00)02009-8 |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| ePrint ID: | 19584 |
| URI: | http://eprints.soton.ac.uk/id/eprint/19584 |
| Deposited On: | 14 Feb 2006 |
| Last Modified: | 01 Jun 2011 00:28 |
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