The University of Southampton
University of Southampton Institutional Repository

Airway inflammation in atopic patients: a comparison of the upper and lower airways

Airway inflammation in atopic patients: a comparison of the upper and lower airways
Airway inflammation in atopic patients: a comparison of the upper and lower airways
Objective. The purpose of this study was to understand and assess the inflammatory response within the upper and lower airways in patients suffering from both asthma and allergic rhinitis. Study Design. Cross-sectional study. Setting. A laboratory-based study of patients with allergic rhinitis and asthma. Subjects and Methods. Glycol methacrylate resin-embedded specimens from 10 patients with allergic rhinitis and asthma taken from the nose and bronchi were assessed by immunohistochemistry. Monoclonal antibodies directed against specific cell markers for mast cells (AA1), eosinophils (EG2), neutrophils (NOE), and lymphocytes (CD3(+), CD4(+), CD8(+)) were studied. Cells were counted blind (as cells/mm(2)) in the submucosal matrix. Mann-Whitney U test was used for analyses. P values of .05 or lower were considered statistically significant. Results. There was a significant increase in CD4(+) (P = .05) and CD8(+) cell counts (P = .001) in the lower airway compared to the upper airway. There were no differences between the 2 groups in the number of neutrophils, mast cells, eosinophils, and the CD3(+) cell counts. Conclusion. The upper and lower airways have parallel inflammation with possible bidirectional extension of inflammation in patients suffering from asthma and allergic rhinitis. There is increased lymphocytic infiltration in the lower airway, suggesting a possible preponderance for development and maintenance of allergic disease in the lower airway.
allergic rhinitis, asthma, mast cells, eosinophils, neutrophils, lymphocytes, nasal mucosa, bronchial mucosa
0194-5998
396-400
Bhimrao, Sanjiv K.
d6982376-eac6-4227-8fd1-498b9d48b662
Wilson, Susan J.
21c6875d-6870-441b-ae7a-603562a646b8
Howarth, Peter H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Bhimrao, Sanjiv K.
d6982376-eac6-4227-8fd1-498b9d48b662
Wilson, Susan J.
21c6875d-6870-441b-ae7a-603562a646b8
Howarth, Peter H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21

Bhimrao, Sanjiv K., Wilson, Susan J. and Howarth, Peter H. (2011) Airway inflammation in atopic patients: a comparison of the upper and lower airways. Otolaryngology Head and Neck Surgery, 145 (3), 396-400. (doi:10.1177/0194599811410531). (PMID:21602533)

Record type: Article

Abstract

Objective. The purpose of this study was to understand and assess the inflammatory response within the upper and lower airways in patients suffering from both asthma and allergic rhinitis. Study Design. Cross-sectional study. Setting. A laboratory-based study of patients with allergic rhinitis and asthma. Subjects and Methods. Glycol methacrylate resin-embedded specimens from 10 patients with allergic rhinitis and asthma taken from the nose and bronchi were assessed by immunohistochemistry. Monoclonal antibodies directed against specific cell markers for mast cells (AA1), eosinophils (EG2), neutrophils (NOE), and lymphocytes (CD3(+), CD4(+), CD8(+)) were studied. Cells were counted blind (as cells/mm(2)) in the submucosal matrix. Mann-Whitney U test was used for analyses. P values of .05 or lower were considered statistically significant. Results. There was a significant increase in CD4(+) (P = .05) and CD8(+) cell counts (P = .001) in the lower airway compared to the upper airway. There were no differences between the 2 groups in the number of neutrophils, mast cells, eosinophils, and the CD3(+) cell counts. Conclusion. The upper and lower airways have parallel inflammation with possible bidirectional extension of inflammation in patients suffering from asthma and allergic rhinitis. There is increased lymphocytic infiltration in the lower airway, suggesting a possible preponderance for development and maintenance of allergic disease in the lower airway.

This record has no associated files available for download.

More information

Published date: September 2011
Keywords: allergic rhinitis, asthma, mast cells, eosinophils, neutrophils, lymphocytes, nasal mucosa, bronchial mucosa
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 197327
URI: http://eprints.soton.ac.uk/id/eprint/197327
ISSN: 0194-5998
PURE UUID: aa81dc7c-50d9-4103-83e5-09deeb96f2a2
ORCID for Susan J. Wilson: ORCID iD orcid.org/0000-0003-1305-8271

Catalogue record

Date deposited: 21 Sep 2011 14:20
Last modified: 14 Mar 2024 04:11

Export record

Altmetrics

Contributors

Author: Sanjiv K. Bhimrao
Author: Susan J. Wilson ORCID iD

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×