A tandem Heck reaction leading to a 26-membered carbocycle
Harrowven, D. C., Woodcock, T. and Howes, P. D. (2002) A tandem Heck reaction leading to a 26-membered carbocycle. Tetrahedron Letters, 43, (51), 9327-9329. (doi:10.1016/S0040-4039(02)02343-2).
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Sequential inter- and intramolecular Heck reactions have been used to construct a 26-membered carbocycle. This new tandem reaction uses strain effects to advantage in biasing the first step towards intermolecular coupling. In the second step, the lack of strain in the formation of a large ring promotes this course over polymerisation.
|Keywords:||palladium-catalyzed vinylation, phase-transfer conditions, organic halides, cyclic carbopalladation, solid support, cyclization, macrocyclization|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||17 Feb 2006|
|Last Modified:||27 Mar 2014 18:09|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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