A tandem Heck reaction leading to a 26-membered carbocycle


Harrowven, D. C., Woodcock, T. and Howes, P. D. (2002) A tandem Heck reaction leading to a 26-membered carbocycle. Tetrahedron Letters, 43, (51), 9327-9329. (doi:10.1016/S0040-4039(02)02343-2).

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Description/Abstract

Sequential inter- and intramolecular Heck reactions have been used to construct a 26-membered carbocycle. This new tandem reaction uses strain effects to advantage in biasing the first step towards intermolecular coupling. In the second step, the lack of strain in the formation of a large ring promotes this course over polymerisation.

Item Type: Article
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Keywords: palladium-catalyzed vinylation, phase-transfer conditions, organic halides, cyclic carbopalladation, solid support, cyclization, macrocyclization
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 19763
Date Deposited: 17 Feb 2006
Last Modified: 27 Mar 2014 18:09
URI: http://eprints.soton.ac.uk/id/eprint/19763

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