A tandem Heck reaction leading to a 26-membered carbocycle

Harrowven, D. C., Woodcock, T. and Howes, P. D. (2002) A tandem Heck reaction leading to a 26-membered carbocycle. Tetrahedron Letters, 43, (51), 9327-9329. (doi:10.1016/S0040-4039(02)02343-2).


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Sequential inter- and intramolecular Heck reactions have been used to construct a 26-membered carbocycle. This new tandem reaction uses strain effects to advantage in biasing the first step towards intermolecular coupling. In the second step, the lack of strain in the formation of a large ring promotes this course over polymerisation.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0040-4039(02)02343-2
Related URLs:
Keywords: palladium-catalyzed vinylation, phase-transfer conditions, organic halides, cyclic carbopalladation, solid support, cyclization, macrocyclization
Subjects: Q Science
Q Science > QD Chemistry
Divisions : University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 19763
Accepted Date and Publication Date:
16 December 2002Published
Date Deposited: 17 Feb 2006
Last Modified: 31 Mar 2016 11:37
URI: http://eprints.soton.ac.uk/id/eprint/19763

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