Novel silyl linkers for solid-phase synthesis
Meloni, M. M., Brown, R. C. D., White, P. D. and Armour, D. (2002) Novel silyl linkers for solid-phase synthesis. Tetrahedron Letters, 43, (34), 6023-6026. (doi:10.1016/S0040-4039(02)01213-3).
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The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1,3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of V alcohols, 2degrees alcohols and phenols to the solid phase. A preliminary study of the stability of the diphenylsiloxane linker towards certain reaction conditions was also carried out. A more reactive silyl chloride resin 10 was found to be suitable for the attachment of 3degrees alcohols to the solid-phase.
|Digital Object Identifier (DOI):||doi:10.1016/S0040-4039(02)01213-3|
|Keywords:||organic-synthesis, strategies, cleavage, triflate, resin|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||17 Feb 2006|
|Last Modified:||06 Aug 2015 02:19|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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