Novel silyl linkers for solid-phase synthesis
Meloni, M. M., Brown, R. C. D., White, P. D. and Armour, D. (2002) Novel silyl linkers for solid-phase synthesis. Tetrahedron Letters, 43, (34), 6023-6026. (doi:10.1016/S0040-4039(02)01213-3).
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Description/Abstract
The syntheses of two silyl chloride resins, 2 and 10 are described starting from Merrifield resin, 3-methyl-1,3-butanediol and diphenyldichlorosilane or dimethyldichlorosilane, respectively. The silyl chloride resin 2 was used for the attachment of V alcohols, 2degrees alcohols and phenols to the solid phase. A preliminary study of the stability of the diphenylsiloxane linker towards certain reaction conditions was also carried out. A more reactive silyl chloride resin 10 was found to be suitable for the attachment of 3degrees alcohols to the solid-phase.
| Item Type: | Article |
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| Related URLs: | |
| Keywords: | organic-synthesis, strategies, cleavage, triflate, resin |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 19818 |
| Date Deposited: | 17 Feb 2006 |
| Last Modified: | 01 Apr 2012 01:04 |
| Contributors: | Meloni, M. M. (Author) Brown, R. C. D. (Author) White, P. D. (Author) Armour, D. (Author) |
| Date: | 19 August 2002 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/19818 |
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