Synthesis of functionalized 1,5-cyclooctadienes by LICKOR metalation


Revell, J. D. and Ganesan, A. (2002) Synthesis of functionalized 1,5-cyclooctadienes by LICKOR metalation. Journal of Organic Chemistry, 67, (17), 6250-6252. (doi: 10.1021/jo025715u).

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Description/Abstract

1,5-Cyclooctadiene was lithiated under LICKOR superbase conditions followed by reaction with alkyl halides or ethylene oxide to yield 3-substituted 1,5-cyclooetadienes in high yield and purity. This procedure is suitable for preparation of 1,5-cyclooctadienes carrying pendant functional groups for immobilization on solid-phase resins.

Item Type: Article
Related URLs:
Keywords: 9-borabicyclononane 9-bbn, organic-synthesis, superbases, route
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
Item ID: 19843
Date Deposited: 20 Feb 2006
Last Modified: 01 Jun 2011 06:14
Contributors: Revell, J. D. (Author)
Ganesan, A. (Author)
Date: 23 August 2002
Status: Published
URI: http://eprints.soton.ac.uk/id/eprint/19843

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