First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine


Sollogoub, M., Fox, K. R., Powers, V. E. C. and Brown, T. (2002) First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine. Tetrahedron Letters, 43, (17), 3121-3123. (doi:10.1016/S0040-4039(02)00481-1).

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Description/Abstract

The synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-nucleosidic analogues of natural nucleosides.

Item Type: Article
Related URLs:
Keywords: glycosides, chemistry, pyridine
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 19860
Date Deposited: 17 Feb 2006
Last Modified: 27 Mar 2014 18:09
URI: http://eprints.soton.ac.uk/id/eprint/19860

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