First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine
Sollogoub, M., Fox, K. R., Powers, V. E. C. and Brown, T. (2002) First synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine. Tetrahedron Letters, 43, (17), 3121-3123. (doi:10.1016/S0040-4039(02)00481-1).
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Original Publication URL: http://dx.doi.org/10.1016/S0040-4039(02)00481-1
Description/Abstract
The synthesis of 1-deazacytidine, the C-nucleoside analogue of cytidine, is described. It involves coupling of a protected 2-amino-5-bromopyridine with perbenzylated ribonolactone and transformation of the pyridine ring into the desired substituted pyridone. This synthesis completes the family of C-nucleosidic analogues of natural nucleosides.
| Item Type: | Article |
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| Related URLs: | |
| Keywords: | glycosides, chemistry, pyridine |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 19860 |
| Date Deposited: | 17 Feb 2006 |
| Last Modified: | 01 Apr 2012 01:05 |
| Contributors: | Sollogoub, M. (Author) Fox, K. R. (Author) Powers, V. E. C. (Author) Brown, T. (Author) |
| Date: | 22 April 2002 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/19860 |
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