The stereospecific synthesis of 'orthogonally' protected lanthionines
Swali, V., Matteucci, M., Elliot, R. and Bradley, M. (2002) The stereospecific synthesis of 'orthogonally' protected lanthionines. Tetrahedron, 58, (44), 9101-9109. (doi:10.1016/S0040-4020(02)01091-8)
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Official URL: http://dx.doi.org/10.1016/S0040-4020(02)01091-8
Description/Abstract
Lanthionine is an attractive monomer for the design and synthesis of novel conformationally constrained peptidomimetics, since unlike cystine, the monosulfur bridge of lanthionine is chemically far more robust and also displays a greater degree of conformational rigidity. The synthesis of lanthionine residues for use in peptide synthesis is non-trivial due to the protectional requirements necessary for this tetra-functional amino acid. In this paper an efficient stereo-specific route to orthogonally protected lanthionine is described.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | lanthionine, peptidomimetics, peptides organic sulfur chemistry, solid-phase synthesis, amino-acids, selectivedesulfurization, peptide-synthesis, n-tritylserine, derivatives, analogs, serine, esters |
| Related URLs: | http://dx.doi.org/10.1016/S004...02)01091-8 |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| ePrint ID: | 19864 |
| URI: | http://eprints.soton.ac.uk/id/eprint/19864 |
| Deposited On: | 17 Feb 2006 |
| Last Modified: | 01 Jun 2011 04:56 |
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