The stereospecific synthesis of 'orthogonally' protected lanthionines
Swali, V., Matteucci, M., Elliot, R. and Bradley, M. (2002) The stereospecific synthesis of 'orthogonally' protected lanthionines. Tetrahedron, 58, (44), 9101-9109. (doi:10.1016/S0040-4020(02)01091-8).
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Lanthionine is an attractive monomer for the design and synthesis of novel conformationally constrained peptidomimetics, since unlike cystine, the monosulfur bridge of lanthionine is chemically far more robust and also displays a greater degree of conformational rigidity. The synthesis of lanthionine residues for use in peptide synthesis is non-trivial due to the protectional requirements necessary for this tetra-functional amino acid. In this paper an efficient stereo-specific route to orthogonally protected lanthionine is described.
|Keywords:||lanthionine, peptidomimetics, peptides organic sulfur chemistry, solid-phase synthesis, amino-acids, selectivedesulfurization, peptide-synthesis, n-tritylserine, derivatives, analogs, serine, esters|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||17 Feb 2006|
|Last Modified:||01 Jun 2011 03:56|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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