Regioselective synthesis of 3-alkylindoles mediated by zinc triflate

Zhu, X. W. and Ganesan, A. (2002) Regioselective synthesis of 3-alkylindoles mediated by zinc triflate. Journal of Organic Chemistry, 67, (8), 2705-2708. (doi:10.1021/jo010996b).


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Zinc triflate was found to be an effective reagent for the C3-alkylation of indoles by alkyl halides in the presence of Hunig's base and tetrabutylammonium iodide. This new method for indole alkylation proceeds by a S(N)1-like pathway, and is general for allylic, benzylic, and tertiary halides.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1021/jo010996b
Related URLs:
Keywords: 3-substituted indoles, tryptophans
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 19873
Date :
Date Event
19 April 2002Published
Date Deposited: 20 Feb 2006
Last Modified: 31 Mar 2016 11:37

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