Regioselective synthesis of 3-alkylindoles mediated by zinc triflate
Zhu, X. W. and Ganesan, A. (2002) Regioselective synthesis of 3-alkylindoles mediated by zinc triflate. Journal of Organic Chemistry, 67, (8), 2705-2708. (doi: 10.1021/jo010996b).
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Zinc triflate was found to be an effective reagent for the C3-alkylation of indoles by alkyl halides in the presence of Hunig's base and tetrabutylammonium iodide. This new method for indole alkylation proceeds by a S(N)1-like pathway, and is general for allylic, benzylic, and tertiary halides.
|Keywords:||3-substituted indoles, tryptophans|
Q Science > QD Chemistry
|Divisions:||University Structure - Pre August 2011 > School of Chemistry
|Date Deposited:||20 Feb 2006|
|Last Modified:||01 Jun 2011 11:03|
|RDF:||RDF+N-Triples, RDF+N3, RDF+XML, Browse.|
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