Strategies for drug delivery to the human inner ear by multifunctional nanoparticles
Strategies for drug delivery to the human inner ear by multifunctional nanoparticles
Hearing loss is a very significant health problem. The methods currently available for inner ear drug delivery are limited and a noninvasive cell-specific drug delivery strategy needs to be found.
Aim: in this study we investigated the ability of polymersomes, lipid core nanocapsules and hyperbranched poly-L-lysine to cross the round window membrane.
Materials & Methods: nanoparticles (NPs) used in this study have different size and chemical compositions. Freshly frozen human temporal bones were used for this investigation. Intact human round window membrane within the freshly frozen human temporal bone served as an excellent model to test the membrane permeation and distribution within the tissues.
Results: in this investigation we were able to visualize the NPs across the round window membrane. The NPs were subsequently found to be distributed in the sensory hair cells, nerve fibers and to other cells of the cochlea.
Conclusion: this finding raises hope in terms of future multifunctional NP-based drug delivery strategy to the human inner ear
55-63
Roy, Soumen
25bd32b7-252d-47c4-9185-436fe23f5614
Glueckert, Rudolf
86983aec-7f03-4823-91ce-e19a5db97286
Johnston, Alex H.
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Perrier, Thomas
677ae345-9295-4fad-9931-ca58545e6324
Newman, T.A.
322290cb-2e9c-445d-a047-00b1bea39a25
Saulnier, Patrick
8ace7954-4a5a-4131-95e7-971a25c02ef0
Schrott-Fischer, Anneliese
82f224c2-3227-4c44-8fcd-e4174496efb8
January 2012
Roy, Soumen
25bd32b7-252d-47c4-9185-436fe23f5614
Glueckert, Rudolf
86983aec-7f03-4823-91ce-e19a5db97286
Johnston, Alex H.
3ae749e9-d566-4a4e-9e77-88ea3c22b470
Perrier, Thomas
677ae345-9295-4fad-9931-ca58545e6324
Newman, T.A.
322290cb-2e9c-445d-a047-00b1bea39a25
Saulnier, Patrick
8ace7954-4a5a-4131-95e7-971a25c02ef0
Schrott-Fischer, Anneliese
82f224c2-3227-4c44-8fcd-e4174496efb8
Roy, Soumen, Glueckert, Rudolf, Johnston, Alex H., Perrier, Thomas, Newman, T.A., Saulnier, Patrick and Schrott-Fischer, Anneliese
(2012)
Strategies for drug delivery to the human inner ear by multifunctional nanoparticles.
Nanomedicine, 7 (1), .
(doi:10.2217/nnm.11.84).
(PMID:22106854)
Abstract
Hearing loss is a very significant health problem. The methods currently available for inner ear drug delivery are limited and a noninvasive cell-specific drug delivery strategy needs to be found.
Aim: in this study we investigated the ability of polymersomes, lipid core nanocapsules and hyperbranched poly-L-lysine to cross the round window membrane.
Materials & Methods: nanoparticles (NPs) used in this study have different size and chemical compositions. Freshly frozen human temporal bones were used for this investigation. Intact human round window membrane within the freshly frozen human temporal bone served as an excellent model to test the membrane permeation and distribution within the tissues.
Results: in this investigation we were able to visualize the NPs across the round window membrane. The NPs were subsequently found to be distributed in the sensory hair cells, nerve fibers and to other cells of the cochlea.
Conclusion: this finding raises hope in terms of future multifunctional NP-based drug delivery strategy to the human inner ear
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Accepted/In Press date: October 2011
Published date: January 2012
Organisations:
Faculty of Medicine
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Local EPrints ID: 198761
URI: http://eprints.soton.ac.uk/id/eprint/198761
ISSN: 1743-5889
PURE UUID: c57cef93-994c-4a51-96ff-f679d80ec448
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Date deposited: 06 Oct 2011 15:34
Last modified: 15 Mar 2024 02:52
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Contributors
Author:
Soumen Roy
Author:
Rudolf Glueckert
Author:
Alex H. Johnston
Author:
Thomas Perrier
Author:
Patrick Saulnier
Author:
Anneliese Schrott-Fischer
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