Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene
Alesso, S. M., Yu, Z. R., Pears, D., Worthington, P. A., Luke, R. W. A. and Bradley, M. (2003) Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene. Tetrahedron, 59, (36), 7163-7169. (doi:10.1016/S0040-4020(03)01100-1).
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Description/Abstract
The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS.
| Item Type: | Article |
|---|---|
| Related URLs: | |
| Keywords: | styrenic methoxypoly(ethylene glycol) (mpeg), monomer, resins, solid supports, solid phase synthesissuspension polymerization, organic-synthesis, peptide-synthesis, supports, acid, catalysts, chemistry, polymers, beads |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| Item ID: | 19878 |
| Date Deposited: | 17 Feb 2006 |
| Last Modified: | 01 Apr 2012 01:05 |
| Contributors: | Alesso, S. M. (Author) Yu, Z. R. (Author) Pears, D. (Author) Worthington, P. A. (Author) Luke, R. W. A. (Author) Bradley, M. (Author) |
| Date: | 1 September 2003 |
| Status: | Published |
| URI: | http://eprints.soton.ac.uk/id/eprint/19878 |
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