Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene


Alesso, S. M., Yu, Z. R., Pears, D., Worthington, P. A., Luke, R. W. A. and Bradley, M. (2003) Improving resins for solid phase synthesis: incorporation of 1- 2-(2-methoxyethoxy)ethoxy -4-vinyl-benzene. Tetrahedron, 59, (36), 7163-7169. (doi:10.1016/S0040-4020(03)01100-1).

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Description/Abstract

The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel(TM), ArgoGel(TM) and aminomethyl PS.

Item Type: Article
Related URLs:
Keywords: styrenic methoxypoly(ethylene glycol) (mpeg), monomer, resins, solid supports, solid phase synthesissuspension polymerization, organic-synthesis, peptide-synthesis, supports, acid, catalysts, chemistry, polymers, beads
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 19878
Date Deposited: 17 Feb 2006
Last Modified: 27 Mar 2014 18:09
URI: http://eprints.soton.ac.uk/id/eprint/19878

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