Trifluoroacetyl as an orthogonal protecting group for guanidines
Bartoli, S., Jensen, K. B. and Kilburn, J. D. (2003) Trifluoroacetyl as an orthogonal protecting group for guanidines. Journal of Organic Chemistry, 68, (24), 9416-9422. (doi: 10.1021/jo0348874)
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Description/Abstract
The trifluoroacetyl moiety has been used as a new protecting group for guanidine functionality. The protecting group is easily cleaved under mild basic conditions and is complementary to the Boc, Cbz, and Ddpe protecting groups. The protecting group can be applied to peptide synthesis in solution as well as on a solid phase as it is orthogonal to a Boc and Cbz strategy and semiorthogonal to an Fmoc strategy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | molecular tweezers, carboxylic-acids, receptor, complexation, recognition, libraries, design, water |
| Related URLs: | http://pubs3.acs.org/acs/journ.../jo0348874 |
| Subjects: | Q Science Q Science > QD Chemistry |
| Divisions: | University Structure - Pre August 2011 > School of Chemistry |
| ePrint ID: | 19893 |
| URI: | http://eprints.soton.ac.uk/id/eprint/19893 |
| Deposited On: | 20 Feb 2006 |
| Last Modified: | 01 Jun 2011 00:30 |
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