Trifluoroacetyl as an orthogonal protecting group for guanidines

Bartoli, S., Jensen, K. B. and Kilburn, J. D. (2003) Trifluoroacetyl as an orthogonal protecting group for guanidines. Journal of Organic Chemistry, 68, (24), 9416-9422. (doi:10.1021/jo0348874).


Full text not available from this repository.


The trifluoroacetyl moiety has been used as a new protecting group for guanidine functionality. The protecting group is easily cleaved under mild basic conditions and is complementary to the Boc, Cbz, and Ddpe protecting groups. The protecting group can be applied to peptide synthesis in solution as well as on a solid phase as it is orthogonal to a Boc and Cbz strategy and semiorthogonal to an Fmoc strategy.

Item Type: Article
Related URLs:
Keywords: molecular tweezers, carboxylic-acids, receptor, complexation, recognition, libraries, design, water
Subjects: Q Science
Q Science > QD Chemistry
Divisions: University Structure - Pre August 2011 > School of Chemistry
ePrint ID: 19893
Date Deposited: 20 Feb 2006
Last Modified: 06 Aug 2015 02:19

Actions (login required)

View Item View Item